Nfyc nuclear transcription factor Y subunit gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nfycprovided by RGD
Official Full Name: nuclear transcription factor Y subunit gammaprovided by RGD
Primary source: RGD:3173
See related: EnsemblRapid:ENSRNOG00000010735 AllianceGenome:RGD:3173
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CBF-C
Summary: Predicted to enable DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to contribute to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of DNA-templated transcription. Part of CCAAT-binding activity factor complex. Orthologous to human NFYC (nuclear transcription factor Y subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 238.9), Heart (RPKM 228.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (139622020..139690545, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (134336802..134405372, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (139687442..139760154, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of NF-YC might play an important role in the pathophysiology via proapoptotic protein Bim after middle cerebral artery occlusion.
Title: Upregulated expression of NF-YC contributes to neuronal apoptosis via proapoptotic protein bim in rats' brain hippocampus following middle cerebral artery occlusion (MCAO).
NF-Y cooperates with FOXO3a to recruit CBP/p300 to the bim promoter to form a stable multi-protein/DNA complex that activates bim transcription after survival factor withdrawal.
Title: NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons.
polyunsaturated fatty acids decrease in vivo binding of NF-Y and SREBP-1c to the proximal promoter of the hepatic fatty acid synthase gene
Title: Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c.
NF-Y binds to p73 and transcriptionally regulates platelet derived growth factor beta receptor
Title: p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127483 (e-PCR)
- UniSTS:210793

RH133216 (e-PCR)
- UniSTS:216499

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
contributes_to transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of CCAAT-binding factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CCAAT-binding factor complex	IDA Inferred from Direct Assay more info	PubMed
part_of CCAAT-binding factor complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear transcription factor Y subunit gamma

Names: CAAT box DNA-binding protein subunit C; CCAAT binding factor of CBF-C/NFY-C; CCAAT-binding transcription factor subunit C; NF-YC; nuclear transcription factor Y subunit C; nuclear transcription factor-Y gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429293.1 → NP_001416222.1 nuclear transcription factor Y subunit gamma isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q566C6, Q62725

UniProtKB/TrEMBL

A6IRZ3
NM_001429294.1 → NP_001416223.1 nuclear transcription factor Y subunit gamma isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q566C6, Q62725

UniProtKB/TrEMBL

A6IRZ3
NM_001429295.1 → NP_001416224.1 nuclear transcription factor Y subunit gamma isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q566C6, Q62725

UniProtKB/TrEMBL

A6IRZ3
NM_001429296.1 → NP_001416225.1 nuclear transcription factor Y subunit gamma isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q566C6, Q62725

UniProtKB/TrEMBL

A6IRZ3
NM_001429297.1 → NP_001416226.1 nuclear transcription factor Y subunit gamma isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005
NM_012866.4 → NP_036998.1 nuclear transcription factor Y subunit gamma isoform 1

See identical proteins and their annotated locations for NP_036998.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q566C6, Q62725

UniProtKB/TrEMBL

A0A8L2R661, A6IRZ3

Related

ENSRNOP00000053489.2, ENSRNOT00000056651.6

Conserved Domains (1) summary

COG5208
Location:17 → 123

HAP5; CCAAT-binding factor, subunit C [Transcription]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

139622020..139690545 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238785.5 → XP_006238847.1 nuclear transcription factor Y subunit gamma isoform X1

Conserved Domains (1) summary

COG5208
Location:17 → 123

HAP5; CCAAT-binding factor, subunit C [Transcription]
XM_017593159.3 → XP_017448648.1 nuclear transcription factor Y subunit gamma isoform X1

Conserved Domains (1) summary

COG5208
Location:17 → 123

HAP5; CCAAT-binding factor, subunit C [Transcription]
XM_039109298.2 → XP_038965226.1 nuclear transcription factor Y subunit gamma isoform X2

Conserved Domains (1) summary

COG5208
Location:17 → 123

HAP5; CCAAT-binding factor, subunit C [Transcription]