Trpc4 transient receptor potential cation channel, subfamily C, member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpc4provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily C, member 4provided by RGD
Primary source: RGD:621276
See related: EnsemblRapid:ENSRNOG00000011133 AllianceGenome:RGD:621276
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trp4; Trrp4
Summary: Enables calcium channel activity. Involved in calcium ion transport; positive regulation of store-operated calcium entry; and regulation of action potential firing rate. Predicted to be located in several cellular components, including basolateral plasma membrane; caveola; and cortical cytoskeleton. Predicted to be part of calcium channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human TRPC4 (transient receptor potential cation channel subfamily C member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 49.8), Uterus (RPKM 18.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q26

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (140457841..140629556)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (138307676..138476856)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (143433102..143605757)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPC4 aggravates hypoxic pulmonary hypertension by promoting pulmonary endothelial cell apoptosis.
Title: TRPC4 aggravates hypoxic pulmonary hypertension by promoting pulmonary endothelial cell apoptosis.
STIM1L/Orai1/TRPC1/C4-dependent Ca(2+) current participates in Ca(2+) remodeling in right ventricular hypertrophy secondary to pulmonary hypertension.
Title: Ca(2+) handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy.
In the trigeminal ganglion (TG), 56.1, 84.1, and 68.3% of sensory neurons were immunoreactive (IR) for TRPC1, TRPC3, and TRPC4, respectively.
Title: TRPC1, TRPC3, and TRPC4 in Rat Orofacial Structures.
1) TRPC1/4 exert protective effects against SAH-induecd EBI, including cortical cell death and degenerating; 2) TRPC1/4 positively regulated the activity of calcineurin. 3) TRPC1/4 promoted the dephosphorylation of NMDAR via calcineurin.
Title: Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation.
The data of this study demonstrated a potentially novel role for TRPC4 channels in dopamine systems and may offer a new pharmacological target for more effective treatment of a variety of dopamine disorders.
Title: Loss of the trpc4 gene is associated with a reduction in cocaine self-administration and reduced spontaneous ventral tegmental area dopamine neuronal activity, without deficits in learning for natural rewards.
Our results show that TRPC4 underlies an exaggerated endothelial permeability response in pulmonary arterial hypertension
Title: Transient Receptor Potential Channel 4 Encodes a Vascular Permeability Defect and High-Frequency Ca(2+) Transients in Severe Pulmonary Arterial Hypertension.
Aldosterone specifically increased the mRNA and/or protein levels of Orai1, TRPC1, -C4, -C5, and stromal interaction molecule 1 through mineralocorticoid receptor activation
Title: Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES.
data provide evidence that TRPC4 is required for detection and/or transmission of colonic mustard oil visceral pain sensation
Title: A rat knockout model implicates TRPC4 in visceral pain sensation.
Hypertrophic response is dependent on the TrpC4alpha splice variant-specific sequence that binds to PIP2.
Title: The phosphatidylinositol(4,5)bisphosphate-binding sequence of transient receptor potential channel canonical 4α is critical for its contribution to cardiomyocyte hypertrophy.
TRPC4 inactivation therefore provides a survival benefit in severe PAH, associated with a decrease in the magnitude of occlusive remodeling.
Title: TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpc4 (e-PCR), detects polymorphism
- UniSTS:531241

RH134901 (e-PCR)
- UniSTS:218179

Trpc4 (e-PCR), detects polymorphism
- UniSTS:516715

Trpc4 (e-PCR), detects polymorphism
- UniSTS:507346

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in gamma-aminobutyric acid secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of store-operated calcium entry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of action potential firing rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cortical cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: short transient receptor potential channel 4

Names: CCE1; capacitative calcium entry channel 1; transient receptor potential channel 4; transient receptor potential protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083115.1 → NP_001076584.1 short transient receptor potential channel 4 isoform beta

See identical proteins and their annotated locations for NP_001076584.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (beta) has multiple differences in the coding region but maintains the reading frame, compared to variant alpha. This variant encodes isoform beta, which is shorter than isoform alpha.

Source sequence(s)

AF421364

UniProtKB/Swiss-Prot

O35119, Q9EQ74, Q9EQ75

UniProtKB/TrEMBL

A6JVB2, F7F3R3, Q91ZM0

Related

ENSRNOP00000015437.4, ENSRNOT00000015437.7

Conserved Domains (2) summary

TIGR00870
Location:17 → 749

trp; transient-receptor-potential calcium channel protein

sd00045
Location:122 → 167

ANK; ANK repeat [structural motif]
NM_080396.1 → NP_536321.1 short transient receptor potential channel 4 isoform alpha

See identical proteins and their annotated locations for NP_536321.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (alpha) encodes the longer isoform (alpha).

Source sequence(s)

AF421363

UniProtKB/Swiss-Prot

O35119, Q9EQ74, Q9EQ75

UniProtKB/TrEMBL

F7FEC4, Q91ZM1

Related

ENSRNOP00000094229.2, ENSRNOT00000101369.2

Conserved Domains (4) summary

cd00204
Location:64 → 168

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:17 → 749

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:176 → 235

TRP_2; Transient receptor ion channel II

sd00045
Location:122 → 167

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

140457841..140629556

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103271.2 → XP_038959199.1 short transient receptor potential channel 4 isoform X3

UniProtKB/Swiss-Prot

O35119, Q9EQ74, Q9EQ75

UniProtKB/TrEMBL

Q91ZL9

Conserved Domains (2) summary

TIGR00870
Location:17 → 749

trp; transient-receptor-potential calcium channel protein

sd00045
Location:122 → 167

ANK; ANK repeat [structural motif]
XM_017591143.3 → XP_017446632.1 short transient receptor potential channel 4 isoform X2

UniProtKB/Swiss-Prot

O35119, Q9EQ74, Q9EQ75

UniProtKB/TrEMBL

A6JVB2, F7F3R3, Q91ZM0

Conserved Domains (2) summary

TIGR00870
Location:17 → 749

trp; transient-receptor-potential calcium channel protein

sd00045
Location:122 → 167

ANK; ANK repeat [structural motif]
XM_006232356.5 → XP_006232418.1 short transient receptor potential channel 4 isoform X1

See identical proteins and their annotated locations for XP_006232418.1

UniProtKB/Swiss-Prot

O35119, Q9EQ74, Q9EQ75

UniProtKB/TrEMBL

F7FEC4, Q91ZM1

Related

ENSRNOP00000042886.2, ENSRNOT00000044028.5

Conserved Domains (4) summary

cd00204
Location:64 → 168

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:17 → 749

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:176 → 235

TRP_2; Transient receptor ion channel II

sd00045
Location:122 → 167

ANK; ANK repeat [structural motif]
XM_039103272.2 → XP_038959200.1 short transient receptor potential channel 4 isoform X4

UniProtKB/TrEMBL

A6JVB3, A6JVB4

Conserved Domains (1) summary

TIGR00870
Location:1 → 329

trp; transient-receptor-potential calcium channel protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_053434.1: Suppressed sequence

Description

NM_053434.1: This RefSeq was permanently suppressed because it contains a frameshift and is a nonsense-mediated mRNA decay (NMD) candidate.