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    Cldn11 claudin 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84588, updated on 2-Nov-2024

    Summary

    Official Symbol
    Cldn11provided by RGD
    Official Full Name
    claudin 11provided by RGD
    Primary source
    RGD:71081
    See related
    EnsemblRapid:ENSRNOG00000010263 AllianceGenome:RGD:71081
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in bicellular tight junction assembly and calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules. Predicted to act upstream of or within axon ensheathment and spermatogenesis. Predicted to be located in several cellular components, including lipid droplet; neurofilament; and tight junction. Predicted to be active in bicellular tight junction and plasma membrane. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 22. Orthologous to human CLDN11 (claudin 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 820.6), Testes (RPKM 320.1) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Cldn11 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (114136234..114149539, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (112207745..112221050, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (115823541..115836846, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 7, member 14 Neighboring gene uncharacterized LOC134485894 Neighboring gene U1 spliceosomal RNA Neighboring gene SKI-like proto-oncogene Neighboring gene uncharacterized LOC102547718

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding  
    enables identical protein binding  
    enables identical protein binding  
    enables structural molecule activity  
    Process Evidence Code Pubs
    involved_in axon ensheathment  
    acts_upstream_of_or_within axon ensheathment  
    involved_in bicellular tight junction assembly  
    involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules  
    involved_in cell adhesion  
    involved_in cell adhesion  
    acts_upstream_of_or_within cell adhesion  
    involved_in spermatogenesis  
    acts_upstream_of_or_within spermatogenesis  
    involved_in tight junction assembly  
    involved_in tight junction assembly  
    Component Evidence Code Pubs
    located_in axon  
    located_in axon  
    located_in basal part of cell  
    located_in basal part of cell  
    is_active_in bicellular tight junction  
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    located_in bicellular tight junction PubMed 
    located_in cell junction  
    located_in lipid droplet  
    located_in lipid droplet  
    located_in neurofilament  
    located_in neurofilament  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in tight junction  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053457.3NP_445909.2  claudin-11

      See identical proteins and their annotated locations for NP_445909.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q99P82
      UniProtKB/TrEMBL
      F7FQF2, Q6IRG7
      Related
      ENSRNOP00000014359.3, ENSRNOT00000014359.7
      Conserved Domains (1) summary
      cl21598
      Location:6172
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      114136234..114149539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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