Slc5a1 solute carrier family 5 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc5a1provided by RGD
Official Full Name: solute carrier family 5 member 1provided by RGD
Primary source: RGD:3713
See related: EnsemblRapid:ENSRNOG00000017775 AllianceGenome:RGD:3713
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SGLT1; SGLT1a
Summary: Enables D-glucose:sodium symporter activity. Predicted to be involved in several processes, including D-glucose transmembrane transport; alpha-glucoside transport; and intestinal D-glucose absorption. Predicted to act upstream of or within D-glucose transmembrane transport; intestinal absorption; and metanephros development. Located in apical plasma membrane; brush border membrane; and cell-cell junction. Human ortholog(s) of this gene implicated in glucose-galactose malabsorption. Orthologous to human SLC5A1 (solute carrier family 5 member 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Kidney (RPKM 121.6) and Lung (RPKM 51.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (81778495..81843084, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (77553990..77618589, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (82910448..82975303, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intermittent high glucose induces pyroptosis of rat H9C2 cardiomyocytes via sodium-glucose cotransporter 1.
Title: Intermittent high glucose induces pyroptosis of rat H9C2 cardiomyocytes via sodium-glucose cotransporter 1.
this study also aims to determine the active ingredients of H. sabdariffa (Hib) that interact with sodium-glucose cotransporter-1 (SGLT-1) so that it can increase GLP-1 secretion in the ileum and interact with GLP-1 receptors (GLP-1R) in the pancreas.
Title: The Potential of Hibiscus sabdariffa Linn in Inducing Glucagon-Like Peptide-1 via SGLT-1 and GLPR in DM Rats.
SGLT1 activity in lung alveolar cells of diabetic rats modulates airway surface liquid glucose concentration and bacterial proliferation.
Title: SGLT1 activity in lung alveolar cells of diabetic rats modulates airway surface liquid glucose concentration and bacterial proliferation.
CG was mainly transported into the small intestinal cells by sodium-dependent glucose transporter 1.
Title: SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats.
Present study indicated that inhibition of SGLT1 by phlorizin abrogated the beneficial effect of ischemic-preconditioning and for the first time, provides evidence that SGLT1 plays a crucial role in ischemic preconditioning-induced cardioprotection.
Title: Inhibition of SGLT1 abrogates preconditioning-induced cardioprotection against ischemia-reperfusion injury.
Elevated SGLT activity increases Na+ influx into myocytes and causes Na+ overload in type 2 diabetes.
Title: Intracellular Na+ Concentration ([Na+]i) Is Elevated in Diabetic Hearts Due to Enhanced Na+-Glucose Cotransport.
Data indicate that there are several alternative channels for urea in the rat inner medulla that could potentially contribute to the high urea permeabilities in thin limb segments.
Title: Alternative channels for urea in the inner medulla of the rat kidney.
These findings suggest that SGLT1 in the ventromedial hypothalamus plays a significant role in the detection and activation of counterregulatory responses to hypoglycemia.
Title: Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats.
glucose stimulates neurotensin secretion by uptake through SGLT1 and GLUT2, both causing depolarization either as a consequence of sodium-coupled uptake (SGLT1) or by closure of KATP channels (GLUT2 and SGLT1) secondary to the ATP-generating metabolism of glucose.
Title: Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2, leading to cell depolarization and calcium influx.
Chronic and direct silencing of basolateral Na-K-ATPase uniquely regulates brush border membrane Na absorptive pathways in intestinal epithelial cells. Specifically, SGLT1 is stimulated secondary to enhanced affinity of the cotransporter.
Title: Chronic and selective inhibition of basolateral membrane Na-K-ATPase uniquely regulates brush border membrane Na absorption in intestinal epithelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (48)

General gene information

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Markers

AU048806 (e-PCR)
- UniSTS:145256

AU048701 (e-PCR)
- UniSTS:145151

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables D-glucose:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables D-glucose:sodium symporter activity	TAS Traceable Author Statement more info	PubMed
enables alpha-glucoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables galactose:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables galactose:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables water transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables water transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in D-glucose import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in D-glucose transmembrane transport	TAS Traceable Author Statement more info	PubMed
involved_in alpha-glucoside transport	ISO Inferred from Sequence Orthology more info
NOT involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in galactose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in intestinal D-glucose absorption	ISO Inferred from Sequence Orthology more info
involved_in intestinal D-glucose absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in intestinal D-glucose absorption	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within intestinal absorption	ISO Inferred from Sequence Orthology more info
involved_in intestinal absorption	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within metanephros development	ISO Inferred from Sequence Orthology more info
involved_in regulation of transporter activity	ISO Inferred from Sequence Orthology more info
involved_in renal D-glucose absorption	ISO Inferred from Sequence Orthology more info
involved_in renal D-glucose absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transepithelial water transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/glucose cotransporter 1

Names: Na(+)/glucose cotransporter 1; Solute carrier family 5, member alpha 1 (Na+/glucose cotransporter); high affinity sodium-glucose cotransporter; solute carrier family 5 (sodium/glucose cotransporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013033.2 → NP_037165.1 sodium/glucose cotransporter 1

See identical proteins and their annotated locations for NP_037165.1

Status: PROVISIONAL

Source sequence(s)

D16101

UniProtKB/Swiss-Prot

P53790, P97787

UniProtKB/TrEMBL

A6IK69, A6IK70

Related

ENSRNOP00000024165.5, ENSRNOT00000024165.8

Conserved Domains (1) summary

cl00456
Location:27 → 665

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain