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    Tgm1 transglutaminase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60335, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Tgm1provided by RGD
    Official Full Name
    transglutaminase 1provided by RGD
    Primary source
    RGD:61838
    See related
    EnsemblRapid:ENSRNOG00000020136 AllianceGenome:RGD:61838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in several processes, including keratinocyte differentiation; peptide cross-linking; and positive regulation of keratinocyte proliferation. Predicted to act upstream of or within animal organ morphogenesis. Predicted to be located in adherens junction and membrane. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1. Orthologous to human TGM1 (transglutaminase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 44.1), Lung (RPKM 20.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tgm1 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33160985..33175632, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29191039..29206000, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34378136..34393150, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene guanosine monophosphate reductase 2 Neighboring gene TERF1 interacting nuclear factor 2 Neighboring gene Rab geranylgeranyltransferase subunit alpha Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease. Johnson TS, et al. J Am Soc Nephrol, 2007 Dec. PMID 18003782
    2. Identification and functional characterization of a novel transglutaminase 1 gene mutation associated with autosomal recessive congenital ichthyosis. Zhang SQ, et al. Int J Dermatol, 2016 Feb. PMID 26220141
    3. Primary structure of keratinocyte transglutaminase. Phillips MA, et al. Proc Natl Acad Sci U S A, 1990 Dec. PMID 1979171, Free PMC Article
    4. Mutations of keratinocyte transglutaminase in lamellar ichthyosis. Huber M, et al. Science, 1995 Jan 27. PMID 7824952
    5. The structure of the transglutaminase 1 enzyme. Deletion cloning reveals domains that regulate its specific activity and substrate specificity. Kim SY, et al. J Biol Chem, 1994 Nov 11. PMID 7961731

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression, activity, and functionality of TG1 and TG2 are decreased in the aorta, but not in the vena cava, from hypertensive rats.
      Title: Transglutaminase activity is decreased in large arteries from hypertensive rats compared with normotensive controls.
    2. Forced expression of TG1 or TG2 proteins is sufficient to induce neuronal death in Rattus norvegicus cortical neurons in vitro.
      Title: Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.
    3. Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease
      Title: Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease.
    4. These molecular and cellular data strongly suggest that TG(R) promotes axonal elongation at the surface of injured RGCs after optic nerve injury.
      Title: Upregulation of retinal transglutaminase during the axonal elongation stage of goldfish optic nerve regeneration.
    5. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
      Title: Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-glutamine gamma-glutamyltransferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide cross-linking NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of keratinocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of keratinocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein-glutamine gamma-glutamyltransferase K
    Names
    TG(K)
    TGK
    TGase K
    TGase-1
    epidermal TGase
    glutamine gamma-glutamyltransferase K
    transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)
    transglutaminase 1, K polypeptide
    transglutaminase K
    NP_113847.1
    XP_006252076.1
    XP_008768913.1
    XP_038949552.1
    XP_063130669.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431338.1 → NP_001418267.1  protein-glutamine gamma-glutamyltransferase K isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P23606, Q4QRA6
      UniProtKB/TrEMBL
      A6KH40

    2. NM_001431339.1 → NP_001418268.1  protein-glutamine gamma-glutamyltransferase K isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P23606, Q4QRA6
      UniProtKB/TrEMBL
      A6KH40

    3. NM_001431340.1 → NP_001418269.1  protein-glutamine gamma-glutamyltransferase K isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    4. NM_001431341.1 → NP_001418270.1  protein-glutamine gamma-glutamyltransferase K isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015

    5. NM_031659.2 → NP_113847.1  protein-glutamine gamma-glutamyltransferase K isoform 1

      See identical proteins and their annotated locations for NP_113847.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P23606, Q4QRA6
      UniProtKB/TrEMBL
      A0A8I5ZX14, A6KH40
      Related
      ENSRNOP00000084357.1, ENSRNOT00000119383.2
      Conserved Domains (3) summary
      smart00460
      Location:379 → 470
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:119 → 234
      Transglut_N; Transglutaminase family
      pfam00927
      Location:699 → 796
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      33160985..33175632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093624.2 → XP_038949552.1  protein-glutamine gamma-glutamyltransferase K isoform X2

      Conserved Domains (3) summary
      smart00460
      Location:343 → 434
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:118 → 234
      Transglut_N; Transglutaminase family
      pfam00927
      Location:663 → 760
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    2. XM_006252014.5 → XP_006252076.1  protein-glutamine gamma-glutamyltransferase K isoform X1

      Related
      ENSRNOP00000027315.2, ENSRNOT00000027315.7
      Conserved Domains (3) summary
      smart00460
      Location:379 → 470
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:119 → 234
      Transglut_N; Transglutaminase family
      pfam00927
      Location:699 → 796
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    3. XM_008770691.4 → XP_008768913.1  protein-glutamine gamma-glutamyltransferase K isoform X1

      Conserved Domains (3) summary
      smart00460
      Location:379 → 470
      TGc; Transglutaminase/protease-like homologues
      pfam00868
      Location:119 → 234
      Transglut_N; Transglutaminase family
      pfam00927
      Location:699 → 796
      Transglut_C; Transglutaminase family, C-terminal ig like domain

    4. XM_063274599.1 → XP_063130669.1  protein-glutamine gamma-glutamyltransferase K isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23606.1 GenPept UniProtKB/Swiss-Prot:P23606

    Gene LinkOut

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