Sftpc surfactant protein C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sftpcprovided by RGD
Official Full Name: surfactant protein Cprovided by RGD
Primary source: RGD:3666
See related: EnsemblRapid:ENSRNOG00000011177 AllianceGenome:RGD:3666
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SP-C
Summary: Enables identical protein binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in alveolar lamellar body; extracellular space; and multivesicular body. Biomarker of bacterial pneumonia and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); and respiratory syncytial virus infectious disease. Orthologous to human SFTPC (surfactant protein C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 56853.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 15p11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (52006274..52009324, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (45596565..45599615, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (52211538..52214480, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of SP-B and SP-C in GDM group was significantly reduced as compared with control group (P<0.05)...It was concluded that gestational diabetes mellitus can cause fetal lung development and maturation disorders, and FOXA2 in fetal lung tissue decreases while nitrocellulose FOXA2 increases
Title: Expression of Lung Surfactant Proteins SP-B and SP-C and Their Regulatory Factors in Fetal Lung of GDM Rats.
SP-C is present on the surface of exocytosed surfactant particles. Antibodies against SP-C stabilize the released particles when contacting the air-liquid interface, precluding their transformation and the formation of surface films. SP-C acts as an essential, preformed molecular key in the initial stages of surfactant unpacking and surface film formation.
Title: A small key unlocks a heavy door: The essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies.
misfolded surfactant protein C has a role in endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells
Title: Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein.
Data show that direct interaction between Foxp2 and Nkx2.1 inhibits Nkx2.1 DNA-binding and transcriptional activity and suggest a mechanism for down-regulation of SP-C during transition of AT2 cells to an AT1 cell phenotype.
Title: Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain.
Results suggest that there is no primary deficiency of surfactant proteins A, B, or C in the nitrofen-induced rat model of congenital diaphragmatic hernia.
Title: Pulmonary surfactant protein A, B, and C mRNA and protein expression in the nitrofen-induced congenital diaphragmatic hernia rat model.
involvement in processing of hydrophobic surfactant-associated protein C in type II pneumocytes
Title: Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes.
Data indicate that heparin can be stimulatory to surfactant protein B and C gene expression depending on concentration, degree of sulfation, and surrounding fibroblast growth factor environment.
Title: Heparin and fibroblast growth factors affect surfactant protein gene expression in type II cells.
NO mediated the decrease in surfactant protein gene expression
Title: Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes.
surfactant protein C processing requires a type II transmembrane topology directed by juxtamembrane positively charged residues
Title: Processing of surfactant protein C requires a type II transmembrane topology directed by juxtamembrane positively charged residues.

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General gene information

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Markers

RH136856 (e-PCR)
- UniSTS:218945

Sftpc (e-PCR), detects polymorphism
- UniSTS:516722

RH94751 (e-PCR)
- UniSTS:119998

RH94752 (e-PCR)
- UniSTS:119999

RH94753 (e-PCR)
- UniSTS:120000

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nitric oxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in respiratory gaseous exchange by respiratory system	IEA Inferred from Electronic Annotation more info
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-6	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in alveolar lamellar body	IBA Inferred from Biological aspect of Ancestor more info
located_in alveolar lamellar body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: surfactant protein C; pulmonary surfactant-associated protein C

Names: Surfactant, pulmonary-associated protein C; pulmonary surfactant-associated proteolipid SPL(Val); surfactant associated protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017342.2 → NP_059038.1 surfactant protein C

See identical proteins and their annotated locations for NP_059038.1

Status: PROVISIONAL

Source sequence(s)

X14221

UniProtKB/Swiss-Prot

P11685, Q52MA6

UniProtKB/TrEMBL

A0A8I6A637, A6HTK9

Related

ENSRNOP00000015032.4, ENSRNOT00000015035.6

Conserved Domains (3) summary

smart00019
Location:1 → 194

SF_P; Pulmonary surfactant proteins

smart01039
Location:95 → 194

BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

pfam08999
Location:1 → 94

SP_C-Propep; Surfactant protein C, N terminal propeptide

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

52006274..52009324 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093609.2 → XP_038949537.1 pulmonary surfactant-associated protein C isoform X1

UniProtKB/TrEMBL

A0A0H2UHI8

Conserved Domains (1) summary

smart00019
Location:22 → 178

SF_P; Pulmonary surfactant proteins