Pi4ka phosphatidylinositol 4-kinase alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pi4kaprovided by RGD
Official Full Name: phosphatidylinositol 4-kinase alphaprovided by RGD
Primary source: RGD:621213
See related: EnsemblRapid:ENSRNOG00000060045 AllianceGenome:RGD:621213
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pik4ca; PI4K-alpha
Summary: Enables 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in several processes, including phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-mediated signaling; and reorganization of cellular membranes to establish viral sites of replication. Predicted to act upstream of or within phosphorylation. Located in Golgi-associated vesicle membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 84. Orthologous to human PI4KA (phosphatidylinositol 4-kinase alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 204.2), Kidney (RPKM 119.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 57

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (97113390..97234374)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (83609148..83726876)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (87858323..87975549)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

palmitoylation is critical for targeting PI4KIIalpha to the trans-Golgi network and for enhancement of its association with low buoyant density membrane fractions
Title: Palmitoylation controls the catalytic activity and subcellular distribution of phosphatidylinositol 4-kinase II{alpha}.
These experiments suggest the participation of PI4K230 in a DNase and RNase sensitive complex with a unique localization and function in the nucleolus.
Title: Nucleolar localization of phosphatidylinositol 4-kinase PI4K230 in various mammalian cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_2765-2766:991933387:1 (e-PCR)
- UniSTS:230946

BE105289 (e-PCR)
- UniSTS:245796

D11Wox17 (e-PCR)
- UniSTS:519004

Pi4ka (e-PCR), detects polymorphism
- UniSTS:546939

RH130116 (e-PCR)
- UniSTS:213404

MHAa22f12.seq (e-PCR)
- UniSTS:125096

D3S1674 (e-PCR)
- UniSTS:148451

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol 4-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol 4-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol 4-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol 4-kinase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in modulation by host of viral process	IEA Inferred from Electronic Annotation more info
involved_in modulation by host of viral process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in reorganization of cellular membranes to establish viral sites of replication	IEA Inferred from Electronic Annotation more info
involved_in reorganization of cellular membranes to establish viral sites of replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi-associated vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phosphatidylinositol 4-kinase alpha

Names: PI4-kinase alpha; leuserpin 2; phosphatidylinositol 4-kinase a; phosphatidylinositol 4-kinase, catalytic, alpha polypeptide; ptdIns-4-kinase alpha

NP_001401943.1

EC 2.7.1.67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.