Gabrq gamma-aminobutyric acid type A receptor subunit theta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabrqprovided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit thetaprovided by RGD
Primary source: RGD:68331
See related: EnsemblRapid:ENSRNOG00000053402 AllianceGenome:RGD:68331
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GABA-A receptor activity and GABA-gated chloride ion channel activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be part of GABA-A receptor complex and transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Orthologous to human GABRQ (gamma-aminobutyric acid type A receptor subunit theta). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Brain (RPKM 13.0), Lung (RPKM 1.9) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (155737838..155755225)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (150696161..150712948)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (152852230..152869012)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our findings suggest that various combinations of GABA(A) alpha3-, theta- and epsilon-subunits may be assembled at a regional and developmental level in the brain.
Title: Expression of GABA(A) receptor alpha3-, theta-, and epsilon-subunit mRNAs during rat CNS development and immunolocalization of the epsilon subunit in developing postnatal spinal cord.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:496008 (e-PCR)
- UniSTS:496008

Gabrq (e-PCR), detects polymorphism
- UniSTS:496008

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-A receptor activity	ISO Inferred from Sequence Orthology more info
enables GABA-gated chloride ion channel activity	ISO Inferred from Sequence Orthology more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit theta

Names: gamma-aminobutyric acid (GABA) A receptor, theta; gamma-aminobutyric acid (GABA) receptor, theta; gamma-aminobutyric acid (GABA-A) receptor, subunit theta; gamma-aminobutyric acid A receptor, theta; gamma-aminobutyric acid type A receptor theta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031733.2 → NP_113921.2 gamma-aminobutyric acid receptor subunit theta precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A6KSY1, G3V875

Related

ENSRNOP00000068820.2, ENSRNOT00000078419.3