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    Gabrr3 gamma-aminobutyric acid type A receptor subunit rho3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192258, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gabrr3provided by RGD
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit rho3provided by RGD
    Primary source
    RGD:621564
    See related
    EnsemblRapid:ENSRNOG00000001679 AllianceGenome:RGD:621564
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GABA-A receptor activity; GABA-gated chloride ion channel activity; and protein domain specific binding activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be part of GABA-A receptor complex and transmembrane transporter complex. Predicted to be active in GABA-ergic synapse; neuron projection; and postsynaptic membrane. Orthologous to human GABRR3 (gamma-aminobutyric acid type A receptor subunit rho3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 5.8), Thymus (RPKM 4.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gabrr3 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (54372017..54424466, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (40902812..40955263, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (43046987..43099754, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene ribosomal oxygenase 2 Neighboring gene NLR family, pyrin domain containing 4A, pseudogene 1 Neighboring gene uncharacterized LOC134480985 Neighboring gene olfactory receptor family 5 subfamily AC member 25 Neighboring gene olfactory receptor family 5 subfamily AC member 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. trans-4-Amino-2-methylbut-2-enoic acid (2-MeTACA) and (+/-)-trans-2-aminomethylcyclopropanecarboxylic acid ((+/-)-TAMP) can differentiate rat rho3 from human rho1 and rho2 recombinant GABA(C) receptors. Vien J, et al. Br J Pharmacol, 2002 Feb. PMID 11861315, Free PMC Article
    2. Cloning of a putative gamma-aminobutyric acid (GABA) receptor subunit rho 3 cDNA. Ogurusu T, et al. Biochim Biophys Acta, 1996 Feb 7. PMID 8605242
    3. Expression of GABArho subunits during rat cerebellum development. Mejía C, et al. Neurosci Lett, 2008 Feb 13. PMID 18201822
    4. ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. Croci C, et al. J Biol Chem, 2003 Feb 21. PMID 12431995
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA-A receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GABA-gated chloride ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transmembrane transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit rho-3
    Names
    GABA receptor rho-3 subunit
    GABA(A) receptor subunit rho-3
    GABA(C) receptor
    GABAAR subunit rho-3
    gamma-aminobutyric acid (GABA) A receptor, rho 3
    gamma-aminobutyric acid (GABA) receptor, rho 3
    gamma-aminobutyric acid type A receptor rho3 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138897.2 → NP_620252.1  gamma-aminobutyric acid receptor subunit rho-3 precursor

      See identical proteins and their annotated locations for NP_620252.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P50573
      UniProtKB/TrEMBL
      A6IQJ1
      Related
      ENSRNOP00000002281.4, ENSRNOT00000002281.6
      Conserved Domains (3) summary
      TIGR00860
      Location:58 → 463
      LIC; Cation transporter family protein
      cd03558
      Location:181 → 195
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:79 → 264
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      54372017..54424466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50573.1 GenPept UniProtKB/Swiss-Prot:P50573

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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