Nat8f3 N-acetyltransferase 8 (GCN5-related) family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nat8f3provided by RGD
Official Full Name: N-acetyltransferase 8 (GCN5-related) family member 3provided by RGD
Primary source: RGD:621607
See related: EnsemblRapid:ENSRNOG00000067962 AllianceGenome:RGD:621607
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable H4 histone acetyltransferase activity. Predicted to be involved in histone H4 acetylation. Predicted to act upstream of or within histone acetylation. Predicted to be located in nuclear membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 169.0), Brain (RPKM 116.8) and 6 other tissues See more
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Genomic context

Location:: 4q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (119799258..119803476, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (118241792..118246010, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (117488089..117492315, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyltransferase activity	NAS Non-traceable Author Statement more info	PubMed
enables histone H4 acetyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in gastrulation with mouth forming second	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acetyltransferase family 8 member 3

Names: N-acetyltransferase CML3; camello-like 3; camello-like protein 3; probable N-acetyltransferase CML3

NP_543159.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080883.1 → NP_543159.1 N-acetyltransferase family 8 member 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q9QXS4

UniProtKB/TrEMBL

A6IAT2

Related

ENSRNOP00000101521.1, ENSRNOT00000134217.1

Conserved Domains (1) summary

pfam13508
Location:107 → 195

Acetyltransf_7; Acetyltransferase (GNAT) domain