Tnfaip6 TNF alpha induced protein 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnfaip6provided by RGD
Official Full Name: TNF alpha induced protein 6provided by RGD
Primary source: RGD:621359
See related: EnsemblRapid:ENSRNOG00000050792 AllianceGenome:RGD:621359
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tnfip6
Summary: Predicted to enable several functions, including carboxylesterase activity; fibronectin binding activity; and hyaluronic acid binding activity. Involved in positive regulation of cell migration. Located in extracellular space. Human ortholog(s) of this gene implicated in corneal neovascularization. Orthologous to human TNFAIP6 (TNF alpha induced protein 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 130.2), Muscle (RPKM 21.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (56911398..56930797)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (36502250..36521652)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (37545238..37564704)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exosomes from LPS-preconditioned bone marrow MSCs accelerated peripheral nerve regeneration via M2 macrophage polarization: Involvement of TSG-6/NF-kappaB/NLRP3 signaling pathway.
Title: Exosomes from LPS-preconditioned bone marrow MSCs accelerated peripheral nerve regeneration via M2 macrophage polarization: Involvement of TSG-6/NF-κB/NLRP3 signaling pathway.
Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted by BMSCs Regulates Activated Astrocytes by Inhibiting NF-kappaB Signaling Pathway to Ameliorate Blood Brain Barrier Damage After Intracerebral Hemorrhage.
Title: Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted by BMSCs Regulates Activated Astrocytes by Inhibiting NF-κB Signaling Pathway to Ameliorate Blood Brain Barrier Damage After Intracerebral Hemorrhage.
HGF and TSG-6 Released by Mesenchymal Stem Cells Attenuate Colon Radiation-Induced Fibrosis.
Title: HGF and TSG-6 Released by Mesenchymal Stem Cells Attenuate Colon Radiation-Induced Fibrosis.
TSG-6 plays a key role in the treatment of ischemia/reperfusion injury-induced acute kidney injury with Bone Marrow Derived Mesenchymal Stromal Cells, which may be due to its effect on promoting renal tubular epithelial cells proliferation by modulating inflammation
Title: Bone Marrow Derived Mesenchymal Stromal Cells Ameliorate Ischemia/Reperfusion Injury-Induced Acute Kidney Injury in Rats via Secreting Tumor Necrosis Factor-Inducible Gene 6 Protein.
Regulate the inflammatory response in LPS-activated BV2 microglia by upregulating TSG-6 expression.
Title: Upregulated TSG-6 Expression in ADSCs Inhibits the BV2 Microglia-Mediated Inflammatory Response.
TSG-6 can inhibit the inflammatory response of transplanted vein grafts in rats and reduce vascular injury by downregulation of P38 and JNK signaling pathway.
Title: Tumor necrosis factor alpha-stimulated gene-6 (TSG-6) inhibits the inflammatory response by inhibiting the activation of P38 and JNK signaling pathway and decreases the restenosis of vein grafts in rats.
This study shows that TSG-6 is expressed in the CNS, suggesting a role for TSG-6 in astrocyte activation and tissue repair.
Title: Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Is Constitutively Expressed in Adult Central Nervous System (CNS) and Associated with Astrocyte-mediated Glial Scar Formation following Spinal Cord Injury.
Reduction of cleaved caspase-3 by TSG-6 treatment demonstrates the putative neuroprotective potential of exogenous TSG-6 administration in inflammation-induced developmental brain injury
Title: Tumor necrosis factor-inducible gene 6 protein: A novel neuroprotective factor against inflammation-induced developmental brain injury.
TSG-6 silenced group (3.36 +/- 0.96 N/mm(2)) showed no benefit over the control group.
Title: TSG-6 mediates the effect of tendon derived stem cells for rotator cuff healing.
Data indicate that TNFalpha-stimulating gene (TSG)-6 (TSG-6) of mesenchymal stem cells (MSCs) was involved in the reduction of peritoneal injury.
Title: Mesenchymal stem cells attenuate peritoneal injury through secretion of TSG-6.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables carboxylesterase activity	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in fibronectin fibril organization	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in ovarian cumulus expansion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor clustering	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor-inducible gene 6 protein

Names: tumor necrosis factor alpha induced protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053382.1 → NP_445834.1 tumor necrosis factor-inducible gene 6 protein precursor

See identical proteins and their annotated locations for NP_445834.1

Status: PROVISIONAL

Source sequence(s)

BC158666

UniProtKB/TrEMBL

A0A9K3Y887, B0BN34, M0R4G8

Related

ENSRNOP00000064253.3, ENSRNOT00000070792.4

Conserved Domains (2) summary

cd03515
Location:36 → 128

Link_domain_TSG_6_like; This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ...

pfam00431
Location:135 → 244

CUB; CUB domain