Slc22a17 solute carrier family 22, member 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc22a17provided by RGD
Official Full Name: solute carrier family 22, member 17provided by RGD
Primary source: RGD:631405
See related: Ensembl:ENSRNOG00000016414 AllianceGenome:RGD:631405
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Boct; 24p3R; rBOCT
Summary: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in siderophore transport. Predicted to be integral component of organelle membrane and integral component of plasma membrane. Orthologous to human SLC22A17 (solute carrier family 22 member 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 700.7), Heart (RPKM 63.7) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (32352273..32358780, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (28382285..28389435, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33569824..33576972, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The gonadal expression pattern of lipocalin2 and 24p3 receptor is modified in the gonads of the offspring of obese rats.
Title: The gonadal expression pattern of lipocalin‑2 and 24p3 receptor is modified in the gonads of the offspring of obese rats.
Influence of renal ischaemia-reperfusion injury on renal neutrophil gelatinase-associated lipocalin receptor (24p3R) in rats.
Title: Influence of renal ischaemia-reperfusion injury on renal neutrophil gelatinase-associated lipocalin receptor (24p3R) in rats.
Lcn2-R upregulation and Lcn2 downregulation via Wnt/beta-catenin may promote adaptive osmotolerant survival of IMCD cells
Title: Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor (SLC22A17) and Lcn2 expression via Wnt/β-catenin signaling in renal inner medullary collecting duct cells: implications for cell fate and bacterial infection.
24p3R binds proteins filtered by the kidney with high affinity and may contribute to receptor-mediated endocy of proteins
Title: Lipocalin-2 (24p3/neutrophil gelatinase-associated lipocalin (NGAL)) receptor is expressed in distal nephron and mediates protein endocytosis.
These novel family members have a nonconserved amino terminus, relative to other organic cation transporters, that may preclude typical SLC22 transport function
Title: Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in siderophore transport	ISO Inferred from Sequence Orthology more info
involved_in siderophore transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in organelle membrane	ISO Inferred from Sequence Orthology more info
located_in organelle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 22 member 17

Names: 24p3 receptor; brain-specific organic ion transporter; brain-type organic cation transporter; lipocalin-2 receptor; solute carrier family 22 (organic cation transporter), member 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177421.3 → NP_803156.2 solute carrier family 22 member 17

See identical proteins and their annotated locations for NP_803156.2

Status: PROVISIONAL

Source sequence(s)

BC099072

UniProtKB/Swiss-Prot

Q4KLP1, Q9P290

UniProtKB/TrEMBL

A0A8I5ZZ20

Related

ENSRNOP00000083004.1, ENSRNOT00000111642.1

Conserved Domains (2) summary

cd06174
Location:106 → 476

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00893
Location:111 → 475

2A0114; D-galactonate transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

32352273..32358780 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251965.2 → XP_006252027.1 solute carrier family 22 member 17 isoform X1

See identical proteins and their annotated locations for XP_006252027.1

UniProtKB/Swiss-Prot

Q4KLP1, Q9P290

UniProtKB/TrEMBL

A0A8I5ZZ20

Related

ENSRNOP00000021851.6

Conserved Domains (2) summary

cd06174
Location:106 → 476

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00893
Location:111 → 475

2A0114; D-galactonate transporter