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    Ddhd2 DDHD domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680971, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Ddhd2provided by RGD
    Official Full Name
    DDHD domain containing 2provided by RGD
    Primary source
    RGD:1585818
    See related
    EnsemblRapid:ENSRNOG00000015501 AllianceGenome:RGD:1585818
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phospholipase activity and triglyceride lipase activity. Predicted to act upstream of or within lipid droplet organization; positive regulation of mitochondrial fission; and triglyceride catabolic process. Predicted to be located in centriolar satellite; cytosol; and membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 54. Orthologous to human DDHD2 (DDHD domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 207.0), Adrenal (RPKM 166.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    16q12.4
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73022136..73051746)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66319469..66349025)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71090096..71120713)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene BAG cochaperone 4 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134482516 Neighboring gene phospholipid phosphatase 5 Neighboring gene nuclear receptor binding SET domain protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase. Araki M, et al. J Biochem, 2016 Nov. PMID 27198176
    2. Protein purification and cloning of diacylglycerol lipase from rat brain. Aso C, et al. J Biochem, 2016 Jun. PMID 26790472, Free PMC Article
    3. The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Inloes JM, et al. Proc Natl Acad Sci U S A, 2014 Oct 14. PMID 25267624, Free PMC Article
    4. Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics. Baba T, et al. J Biol Chem, 2014 Apr 18. PMID 24599962, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triglyceride lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables triglyceride lipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within visual learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase DDHD2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318416.1 → NP_001305345.1  phospholipase DDHD2

      Status: PROVISIONAL

      Source sequence(s)
      AB914679
      UniProtKB/TrEMBL
      A0A8I6AUM0, D3ZJ91
      Conserved Domains (4) summary
      smart00454
      Location:386 → 445
      SAM; Sterile alpha motif
      pfam02825
      Location:42 → 112
      WWE; WWE domain
      pfam02862
      Location:487 → 687
      DDHD; DDHD domain
      cl15755
      Location:379 → 447
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      73022136..73051746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001059724.8 → XP_001059724.3  phospholipase DDHD2 isoform X1

      See identical proteins and their annotated locations for XP_001059724.3

      UniProtKB/TrEMBL
      A0A8I6AUM0, D3ZJ91
      Conserved Domains (4) summary
      smart00454
      Location:386 → 445
      SAM; Sterile alpha motif
      pfam02825
      Location:42 → 112
      WWE; WWE domain
      pfam02862
      Location:487 → 687
      DDHD; DDHD domain
      cl15755
      Location:379 → 447
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_006253339.5 → XP_006253401.1  phospholipase DDHD2 isoform X1

      See identical proteins and their annotated locations for XP_006253401.1

      UniProtKB/TrEMBL
      A0A8I6AUM0, D3ZJ91
      Related
      ENSRNOP00000020832.8, ENSRNOT00000020832.10
      Conserved Domains (4) summary
      smart00454
      Location:386 → 445
      SAM; Sterile alpha motif
      pfam02825
      Location:42 → 112
      WWE; WWE domain
      pfam02862
      Location:487 → 687
      DDHD; DDHD domain
      cl15755
      Location:379 → 447
      SAM_superfamily; SAM (Sterile alpha motif )

    3. XM_063275720.1 → XP_063131790.1  phospholipase DDHD2 isoform X2

      UniProtKB/TrEMBL
      D3ZJ91
      Related
      ENSRNOP00000096096.2, ENSRNOT00000117689.2

    4. XM_008771368.3 → XP_008769590.1  phospholipase DDHD2 isoform X2

      See identical proteins and their annotated locations for XP_008769590.1

      UniProtKB/TrEMBL
      D3ZJ91
      Related
      ENSRNOP00000105009.1, ENSRNOT00000163681.1
      Conserved Domains (4) summary
      smart00454
      Location:386 → 445
      SAM; Sterile alpha motif
      pfam02825
      Location:42 → 112
      WWE; WWE domain
      pfam02862
      Location:470 → 670
      DDHD; DDHD domain
      cl15755
      Location:379 → 447
      SAM_superfamily; SAM (Sterile alpha motif )

    5. XM_039094820.2 → XP_038950748.1  phospholipase DDHD2 isoform X3

      UniProtKB/TrEMBL
      D3ZJ91
      Conserved Domains (3) summary
      pfam02825
      Location:44 → 112
      WWE; WWE domain
      pfam02862
      Location:487 → 672
      DDHD; DDHD domain
      cl15755
      Location:379 → 447
      SAM_superfamily; SAM (Sterile alpha motif )

    6. XM_063275721.1 → XP_063131791.1  phospholipase DDHD2 isoform X4

      UniProtKB/TrEMBL
      D3ZJ91

    7. XM_006253338.4 → XP_006253400.1  phospholipase DDHD2 isoform X5

      See identical proteins and their annotated locations for XP_006253400.1

      UniProtKB/TrEMBL
      D3ZJ91
      Conserved Domains (3) summary
      smart00454
      Location:290 → 349
      SAM; Sterile alpha motif
      pfam02862
      Location:391 → 591
      DDHD; DDHD domain
      cl15755
      Location:283 → 351
      SAM_superfamily; SAM (Sterile alpha motif )

    RNA

    1. XR_005494673.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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