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    Dpy30 dpy-30 histone methyltransferase complex regulatory subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286897, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Dpy30provided by RGD
    Official Full Name
    dpy-30 histone methyltransferase complex regulatory subunitprovided by RGD
    Primary source
    RGD:708575
    See related
    EnsemblRapid:ENSRNOG00000027126 AllianceGenome:RGD:708575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aip1
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in endosomal transport; histone H3-K4 methylation; and subtelomeric heterochromatin assembly. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be part of MLL3/4 complex and Set1C/COMPASS complex. Orthologous to human DPY30 (dpy-30 histone methyltransferase complex regulatory subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 280.6), Thymus (RPKM 273.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dpy30 in Genome Data Viewer
    Location:
    6q13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (26872812..26893580)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (21120947..21141720)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (22296128..22316894)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692563 Neighboring gene spastin Neighboring gene ribosomal protein L18A, pseudogene 5 Neighboring gene uncharacterized LOC120103480 Neighboring gene mediator of cell motility 1 Neighboring gene small nuclear ribonucleoprotein Sm D2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking. Xu Z, et al. J Cell Biol, 2009 Aug 10. PMID 19651892, Free PMC Article
    2. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. Patel A, et al. J Biol Chem, 2009 Sep 4. PMID 19556245, Free PMC Article
    3. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Wu M, et al. Mol Cell Biol, 2008 Dec. PMID 18838538, Free PMC Article
    4. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Shilatifard A. Annu Rev Biochem, 2012. PMID 22663077, Free PMC Article
    5. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. Cho YW, et al. J Biol Chem, 2007 Jul 13. PMID 17500065, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosomal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL1/2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL3/4 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Set1C/COMPASS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Set1C/COMPASS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone methyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein dpy-30 homolog
    Names
    dpy-30 homolog
    dpy-30-like protein
    dpy-30L
    protein rAIP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170545.1 → NP_001164016.1  protein dpy-30 homolog

      See identical proteins and their annotated locations for NP_001164016.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BP474453, FM121127
      UniProtKB/Swiss-Prot
      Q8K3E7
      UniProtKB/TrEMBL
      A6H9Y8
      Related
      ENSRNOP00000110515.1, ENSRNOT00000156805.1
      Conserved Domains (1) summary
      pfam05186
      Location:52 → 93
      Dpy-30; Dpy-30 motif

    2. NM_173117.2 → NP_775140.2  protein dpy-30 homolog

      See identical proteins and their annotated locations for NP_775140.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY129401, BP474453
      UniProtKB/Swiss-Prot
      Q8K3E7
      UniProtKB/TrEMBL
      A6H9Y8
      Conserved Domains (1) summary
      pfam05186
      Location:52 → 93
      Dpy-30; Dpy-30 motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      26872812..26893580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3E7.1 GenPept UniProtKB/Swiss-Prot:Q8K3E7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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