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    Dpagt1 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300668, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dpagt1provided by RGD
    Official Full Name
    dolichyl-phosphate N-acetylglucosaminephosphotransferase 1provided by RGD
    Primary source
    RGD:735124
    See related
    Ensembl:ENSRNOG00000009799 AllianceGenome:RGD:735124
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    H2afx
    Summary
    Enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity. Involved in UDP-N-acetylglucosamine metabolic process; dolichol metabolic process; and dolichol-linked oligosaccharide biosynthetic process. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ij and congenital myasthenic syndrome 13. Orthologous to human DPAGT1 (dolichyl-phosphate N-acetylglucosaminephosphotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 102.5), Heart (RPKM 102.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dpagt1 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53560869..53567625)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44664055..44671102)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48657779..48664531)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene histone H4 transcription factor Neighboring gene C2CD2-like Neighboring gene H2A.X variant histone Neighboring gene hydroxymethylbilane synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effect of GTP on the dolichol pathway for protein glycosylation in rat liver microsomes. Bossuyt X, et al. Biochem J, 1993 Dec 15. PMID 8280061, Free PMC Article
    2. GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation. Yoo J, et al. Nat Struct Mol Biol, 2018 Mar. PMID 29459785, Free PMC Article
    3. Deficiency of UDP-GlcNAc:Dolichol Phosphate N-Acetylglucosamine-1 Phosphate Transferase (DPAGT1) causes a novel congenital disorder of Glycosylation Type Ij. Wu X, et al. Hum Mutat, 2003 Aug. PMID 12872255
    4. Cloning and functional expression of the human GlcNAc-1-P transferase, the enzyme for the committed step of the dolichol cycle, by heterologous complementation in Saccharomyces cerevisiae. Eckert V, et al. Glycobiology, 1998 Jan. PMID 9451016
    5. Major defect of carbohydrate-deficient-glycoprotein syndrome is not found in the synthesis of dolichyl phosphate or N-acetylglucosaminyl-pyrophosphoryl-dolichol. Yasugi E, et al. Biochem Biophys Res Commun, 1994 Apr 29. PMID 8179616

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dolichol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dolichol-linked oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
    Names
    dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
    dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
    NP_955420.1
    XP_006242983.1
    XP_017451039.1
    XP_038936981.1
    XP_038936982.1
    XP_038936983.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199388.2 → NP_955420.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

      See identical proteins and their annotated locations for NP_955420.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      Q6P4Z8
      Conserved Domains (1) summary
      cd06855
      Location:31 → 319
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53560869..53567625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081055.2 → XP_038936983.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X5

      Conserved Domains (1) summary
      cd06855
      Location:31 → 215
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

    2. XM_039081053.2 → XP_038936981.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X1

      UniProtKB/TrEMBL
      F7EMK2
      Related
      ENSRNOP00000013134.3
      Conserved Domains (1) summary
      cd06855
      Location:31 → 319
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

    3. XM_017595550.3 → XP_017451039.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X2

      Conserved Domains (1) summary
      cd06855
      Location:31 → 319
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

    4. XM_006242921.5 → XP_006242983.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X3

      Conserved Domains (1) summary
      cd06855
      Location:31 → 319
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

    5. XM_039081054.2 → XP_038936982.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X4

      UniProtKB/TrEMBL
      A6J3X0
      Conserved Domains (1) summary
      cd06855
      Location:1 → 210
      GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
    Nucleotide Protein Strain
    Heading Accession and Version

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