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    Ephb4 EPH receptor B4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686310, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ephb4provided by RGD
    Official Full Name
    EPH receptor B4provided by RGD
    Primary source
    RGD:1583193
    See related
    EnsemblRapid:ENSRNOG00000045952 AllianceGenome:RGD:1583193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ephrin receptor activity. Predicted to be involved in several processes, including circulatory system development; ephrin receptor signaling pathway; and protein autophosphorylation. Predicted to act upstream of or within positive regulation of T cell costimulation; positive regulation of aorta morphogenesis; and venous blood vessel morphogenesis. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in central conducting lymphatic anomaly. Orthologous to human EPHB4 (EPH receptor B4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 196.6), Kidney (RPKM 173.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ephb4 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24963174..24988473, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19326411..19351667, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22393338..22418332, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene erythropoietin Neighboring gene zonadhesin Neighboring gene uncharacterized LOC134481172 Neighboring gene uncharacterized LOC103691283 Neighboring gene solute carrier family 12, member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Extracellular signal-regulated kinase inhibition prevents venous adaptive remodeling via regulation of Eph-B4. Guo Y, et al. Vascular, 2022 Feb. PMID 33706642
    2. Imbalanced EphB4/EphrinB2 Signaling Modulates Bone Resorption in Periodontitis Induced by Porphyromonas gingivalis. Fu Y, et al. ACS Infect Dis, 2024 Apr 12. PMID 38442009
    3. EphB4 expression and biological significance in prostate cancer. Xia G, et al. Cancer Res, 2005 Jun 1. PMID 15930280
    4. Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily. Bennett BD, et al. J Biol Chem, 1994 May 13. PMID 8188704
    5. Expression levels of EPHB4, EFNB2 and caspase-8 are associated with clinicopathological features and progression of esophageal squamous cell cancer. Ni Q, et al. Oncol Lett, 2020 Jan. PMID 31885720, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Imbalanced EphB4/EphrinB2 Signaling Modulates Bone Resorption in Periodontitis Induced by Porphyromonas gingivalis.
      Title: Imbalanced EphB4/EphrinB2 Signaling Modulates Bone Resorption in Periodontitis Induced by Porphyromonas gingivalis.
    2. Extracellular signal-regulated kinase inhibition prevents venous adaptive remodeling via regulation of Eph-B4.
      Title: Extracellular signal-regulated kinase inhibition prevents venous adaptive remodeling via regulation of Eph-B4.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ephrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of aorta morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within venous blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ephrin type-B receptor 4
    NP_001414515.1
    XP_003751205.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427586.1 → NP_001414515.1  ephrin type-B receptor 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J030
      Related
      ENSRNOP00000092640.1, ENSRNOT00000118505.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      24963174..24988473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003751157.6 → XP_003751205.1  ephrin type-B receptor 4 isoform X1

      See identical proteins and their annotated locations for XP_003751205.1

      UniProtKB/TrEMBL
      A0A8I6GKB3, M0RDA4
      Related
      ENSRNOP00000067602.3, ENSRNOT00000072208.4
      Conserved Domains (7) summary
      cd05065
      Location:619 → 887
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09554
      Location:916 → 982
      SAM_EPH-B4; SAM domain of EPH-B4 subfamily of tyrosine kinase receptors
      smart00454
      Location:913 → 980
      SAM; Sterile alpha motif
      cd10474
      Location:17 → 196
      EphR_LBD_B4; Ligand Binding Domain of Ephrin type-B Receptor 4
      cd00063
      Location:443 → 535
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07714
      Location:624 → 883
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:571 → 619
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    Nucleotide Protein Strain
    Heading Accession and Version

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