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    Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302981, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Spsb3provided by RGD
    Official Full Name
    splA/ryanodine receptor domain and SOCS box containing 3provided by RGD
    Primary source
    RGD:1310936
    See related
    EnsemblRapid:ENSRNOG00000015300 AllianceGenome:RGD:1310936
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tce1
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of cGAS/STING signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein K48-linked ubiquitination. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human SPSB3 (splA/ryanodine receptor domain and SOCS box containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 255.3), Kidney (RPKM 212.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spsb3 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14411692..14417357)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13907175..13912841)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14248199..14253815)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 67 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene NUBP iron-sulfur cluster assembly factor 2 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cGAS/STING signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cGAS/STING signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SPRY domain-containing SOCS box protein 3
    Names
    T-complex expressed gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106988.1 → NP_001100458.1  SPRY domain-containing SOCS box protein 3

      See identical proteins and their annotated locations for NP_001100458.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A0G2JZI4, A6HCY2
      Conserved Domains (2) summary
      cd12876
      Location:139 → 321
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:311 → 347
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14411692..14417357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597221.3 → XP_017452710.1  SPRY domain-containing SOCS box protein 3 isoform X1

    2. XM_063268918.1 → XP_063124988.1  SPRY domain-containing SOCS box protein 3 isoform X3

      Related
      ENSRNOP00000101037.1, ENSRNOT00000173598.1

    3. XM_017597222.3 → XP_017452711.1  SPRY domain-containing SOCS box protein 3 isoform X6

      Related
      ENSRNOP00000020733.6, ENSRNOT00000020733.7

    4. XM_017597223.3 → XP_017452712.1  SPRY domain-containing SOCS box protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JZI4
      Related
      ENSRNOP00000112142.1, ENSRNOT00000131934.1

    5. XM_039085867.2 → XP_038941795.1  SPRY domain-containing SOCS box protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZI4
      Conserved Domains (2) summary
      cd12876
      Location:143 → 350
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:340 → 376
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    6. XM_063268919.1 → XP_063124989.1  SPRY domain-containing SOCS box protein 3 isoform X8

      UniProtKB/TrEMBL
      D3ZVU8
      Related
      ENSRNOP00000071059.3, ENSRNOT00000077689.3

    7. XM_017597224.3 → XP_017452713.1  SPRY domain-containing SOCS box protein 3 isoform X2

    8. XM_017597227.3 → XP_017452716.1  SPRY domain-containing SOCS box protein 3 isoform X5

      Conserved Domains (2) summary
      cd12876
      Location:139 → 346
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:336 → 372
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    9. XM_039085870.2 → XP_038941798.1  SPRY domain-containing SOCS box protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JZI4
      Conserved Domains (2) summary
      cd12876
      Location:143 → 350
      SPRY_SOCS3; SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
      cl02533
      Location:340 → 376
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    10. XM_063268920.1 → XP_063124990.1  SPRY domain-containing SOCS box protein 3 isoform X9

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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