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    Dock5 dedicator of cytokinesis 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305987, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Dock5provided by RGD
    Official Full Name
    dedicator of cytokinesis 5provided by RGD
    Primary source
    RGD:1306872
    See related
    Ensembl:ENSRNOG00000024703 AllianceGenome:RGD:1306872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of vascular associated smooth muscle contraction; positive regulation of cell migration; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to be located in cytosol and plasma membrane. Orthologous to human DOCK5 (dedicator of cytokinesis 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 115.1), Lung (RPKM 97.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dock5 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    54
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (46155124..46334127, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (41979728..42158733, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (44449108..44627774, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 2 Neighboring gene uncharacterized LOC103693653 Neighboring gene potassium channel tetramerization domain containing 9 Neighboring gene gonadotropin releasing hormone 1 Neighboring gene ribosomal protein S16, pseudogene 5 Neighboring gene neurofilament light chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse. Omi N, et al. Exp Eye Res, 2008 May. PMID 18396277
    2. Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins. Kang H, et al. J Biol Chem, 2012 Feb 3. PMID 22158624, Free PMC Article
    3. DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. Sanders MA, et al. J Biol Chem, 2009 Jan 2. PMID 19004829, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within bone remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myoblast fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of vascular associated smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within podosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372012.1 → NP_001358941.1  dedicator of cytokinesis protein 5

      Status: VALIDATED

      Source sequence(s)
      FQ131230, JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZK89, A0A8I6ARJ2
      Related
      ENSRNOP00000077193.1, ENSRNOT00000112046.1
      Conserved Domains (4) summary
      cd11708
      Location:1238 → 1637
      DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5
      cd12051
      Location:12 → 67
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:75 → 434
      DOCK_N; DOCK N-terminus
      cl14603
      Location:442 → 637
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      46155124..46334127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093338.2 → XP_038949266.1  dedicator of cytokinesis protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARJ2
      Related
      ENSRNOP00000094403.1
      Conserved Domains (3) summary
      cd11708
      Location:1205 → 1604
      DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5
      pfam16172
      Location:42 → 401
      DOCK_N; DOCK N-terminus
      cl14603
      Location:409 → 604
      C2; C2 domain

    2. XM_063274295.1 → XP_063130365.1  dedicator of cytokinesis protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARJ2

    3. XM_039093339.2 → XP_038949267.1  dedicator of cytokinesis protein 5 isoform X2

      Conserved Domains (4) summary
      pfam16172
      Location:75 → 434
      DOCK_N; DOCK N-terminus
      cl06123
      Location:1238 → 1534
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
      cl14603
      Location:442 → 637
      C2; C2 domain
      cl17036
      Location:12 → 67
      SH3; Src Homology 3 domain superfamily

    RNA

    1. XR_010057823.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107274.1: Suppressed sequence

      Description
      NM_001107274.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: DOCK5 (GeneID:80005).
    Nucleotide Protein Strain
    Heading Accession and Version

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