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    Kif3b kinesin family member 3B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296284, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Kif3bprovided by RGD
    Official Full Name
    kinesin family member 3Bprovided by RGD
    Primary source
    RGD:1306815
    See related
    EnsemblRapid:ENSRNOG00000010361 AllianceGenome:RGD:1306815
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables microtubule binding activity. Involved in positive regulation of cytokinesis. Located in axon; midbody; and spindle. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Orthologous to human KIF3B (kinesin family member 3B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 158.1), Brain (RPKM 105.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif3b in Genome Data Viewer
    Location:
    3q41
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (162218621..162258191)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (141758466..141798012)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (148772937..148813342)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene protein O-fucosyltransferase 1 Neighboring gene ribosomal protein L27A like 6 Neighboring gene uncharacterized LOC134486328 Neighboring gene ASXL transcriptional regulator 1 Neighboring gene nucleolar protein 4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Temporal and spatial expression of KIF3B after acute spinal cord injury in adult rats. Yu X, et al. J Mol Neurosci, 2013 Feb. PMID 23093447
    2. miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target. Aguado-Fraile E, et al. PLoS One, 2012. PMID 22962609, Free PMC Article
    3. A role for the spectrin superfamily member Syne-1 and kinesin II in cytokinesis. Fan J, et al. J Cell Sci, 2004 Feb 1. PMID 14709720
    4. KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles. Muresan V, et al. Mol Biol Cell, 1998 Mar. PMID 9487132, Free PMC Article
    5. Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10. Aoki T, et al. BMC Cell Biol, 2009 Jul 28. PMID 19635168, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIF3B gene expression in neurons and microglia is upregulated after spinal cord injury.
      Title: Temporal and spatial expression of KIF3B after acute spinal cord injury in adult rats.
    2. A novel role for miR-127 has been shown in cell adhesion and its regulation by HIF-1alpha. KIF3B is identified for the first time as a miR-127 target.
      Title: miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intraciliary transport particle B binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport of neurotransmitter receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in opsin transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin II complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF3B
    NP_001099999.1
    XP_006235349.1
    XP_006235350.1
    XP_006235351.1
    XP_038960533.1
    XP_063139434.1
    XP_063139435.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106529.1 → NP_001099999.1  kinesin-like protein KIF3B

      See identical proteins and their annotated locations for NP_001099999.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474050
      UniProtKB/TrEMBL
      A6KHU9, D3ZI07
      Related
      ENSRNOP00000013804.5, ENSRNOT00000013804.8
      Conserved Domains (2) summary
      COG1196
      Location:352 → 614
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01371
      Location:8 → 340
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      162218621..162258191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283365.1 → XP_063139435.1  kinesin-like protein KIF3B isoform X2

    2. XM_039104605.2 → XP_038960533.1  kinesin-like protein KIF3B isoform X1

      UniProtKB/TrEMBL
      A6KHU9, D3ZI07
      Conserved Domains (2) summary
      COG1196
      Location:352 → 614
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01371
      Location:8 → 340
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

    3. XM_063283364.1 → XP_063139434.1  kinesin-like protein KIF3B isoform X1

      UniProtKB/TrEMBL
      A6KHU9, D3ZI07

    4. XM_006235288.3 → XP_006235350.1  kinesin-like protein KIF3B isoform X1

      See identical proteins and their annotated locations for XP_006235350.1

      UniProtKB/TrEMBL
      A6KHU9, D3ZI07
      Related
      ENSRNOP00000101679.1, ENSRNOT00000152985.1
      Conserved Domains (2) summary
      COG1196
      Location:352 → 614
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01371
      Location:8 → 340
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

    5. XM_006235289.5 → XP_006235351.1  kinesin-like protein KIF3B isoform X1

      See identical proteins and their annotated locations for XP_006235351.1

      UniProtKB/TrEMBL
      A6KHU9, D3ZI07
      Conserved Domains (2) summary
      COG1196
      Location:352 → 614
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01371
      Location:8 → 340
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

    6. XM_006235287.5 → XP_006235349.1  kinesin-like protein KIF3B isoform X1

      See identical proteins and their annotated locations for XP_006235349.1

      UniProtKB/TrEMBL
      A6KHU9, D3ZI07
      Conserved Domains (2) summary
      COG1196
      Location:352 → 614
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01371
      Location:8 → 340
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

    RNA

    1. XR_010064591.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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