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    Suz12 SUZ12 polycomb repressive complex 2 subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688041, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Suz12provided by RGD
    Official Full Name
    SUZ12 polycomb repressive complex 2 subunitprovided by RGD
    Primary source
    RGD:1593621
    See related
    Ensembl:ENSRNOG00000058663 AllianceGenome:RGD:1593621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including nucleic acid binding activity; promoter-specific chromatin binding activity; and transcription corepressor binding activity. Involved in several processes, including histone H3-K27 trimethylation; negative regulation of macromolecule metabolic process; and response to retinoic acid. Predicted to be located in nuclear body; nucleolus; and sex chromatin. Predicted to be part of nucleus; protein-DNA complex; and ribonucleoprotein complex. Biomarker of spina bifida. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 186.3), Thymus (RPKM 161.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Suz12 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (65464948..65510846)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (64967035..65012916)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (67325101..67371588)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L12-like Neighboring gene ribosomal protein L12, pseudogene 8 Neighboring gene ribosomal protein L12, pseudogene 6 Neighboring gene cytokine receptor-like factor 3 Neighboring gene ATPase family, AAA domain containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The histone H3K27 methylation mark regulates intestinal epithelial cell density-dependent proliferation and the inflammatory response. Turgeon N, et al. J Cell Biochem, 2013 May. PMID 23192652, Free PMC Article
    2. Polycomblike protein PHF1b: a transcriptional sensor for GABA receptor activity. Saha S, et al. BMC Pharmacol Toxicol, 2013 Jul 23. PMID 23879974, Free PMC Article
    3. Polycomb group proteins are essential for spinal cord development. Wang C, et al. Front Biosci (Landmark Ed), 2010 Jun 1. PMID 20515739
    4. Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Klattenhoff CA, et al. Cell, 2013 Jan 31. PMID 23352431, Free PMC Article
    5. Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome. Imagawa E, et al. Hum Mutat, 2017 Jun. PMID 28229514

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lncRNA OL1 interacts with Suz12-PRC2 complex to orchestrate the oligodendrocyte differentiation program.
      Title: lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lncRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in facultative heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of chemokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within random inactivation of X chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to retinoic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in spinal cord development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin silencing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of sex chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polycomb protein SUZ12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427659.1 → NP_001414588.1  polycomb protein SUZ12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K2I0, A0A8I6AIG5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      65464948..65510846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087645.2 → XP_038943573.1  polycomb protein SUZ12 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JV08, A0A0G2K2I0
      Related
      ENSRNOP00000069305.2
      Conserved Domains (1) summary
      pfam09733
      Location:522 → 656
      VEFS-Box; VEFS-Box of polycomb protein

    2. XM_039087646.2 → XP_038943574.1  polycomb protein SUZ12 isoform X2

      UniProtKB/TrEMBL
      A6HH95
      Conserved Domains (1) summary
      pfam09733
      Location:248 → 382
      VEFS-Box; VEFS-Box of polycomb protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.