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    Gtpbp2 GTP binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363195, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gtpbp2provided by RGD
    Official Full Name
    GTP binding protein 2provided by RGD
    Primary source
    RGD:1306367
    See related
    EnsemblRapid:ENSRNOG00000019332 AllianceGenome:RGD:1306367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity; identical protein binding activity; and nucleic acid binding activity. Predicted to be involved in translational elongation. Predicted to act upstream of or within nuclear-transcribed mRNA catabolic process, no-go decay and rescue of stalled ribosome. Orthologous to human GTPBP2 (GTP binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 105.5), Lung (RPKM 72.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtpbp2 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22311532..22321405, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14813964..14823419, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17198957..17208456, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene exportin 5 Neighboring gene DNA polymerase eta Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene ribosomal protein S2, pseudogene 6 Neighboring gene MAD2L1 binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. Ishimura R, et al. Science, 2014 Jul 25. PMID 25061210, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-aminoacyl-tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables translation elongation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, no-go decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013225.2 → NP_001013243.2  GTP-binding protein 2

      See identical proteins and their annotated locations for NP_001013243.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K9J3, A6JIT1, D4ABV1
      Related
      ENSRNOP00000026195.5, ENSRNOT00000026195.8
      Conserved Domains (1) summary
      COG5258
      Location:59 → 588
      GTPBP1; GTPase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      22311532..22321405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244543.5 → XP_006244605.1  GTP-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJA2
      Related
      ENSRNOP00000093692.2, ENSRNOT00000104572.2
      Conserved Domains (1) summary
      COG5258
      Location:28 → 561
      GTPBP1; GTPase [General function prediction only]

    2. XM_063267360.1 → XP_063123430.1  GTP-binding protein 2 isoform X1

    3. XM_039083823.2 → XP_038939751.1  GTP-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZWL9
      Related
      ENSRNOP00000083263.2, ENSRNOT00000094924.2
      Conserved Domains (2) summary
      cd04165
      Location:174 → 394
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      COG5258
      Location:59 → 541
      GTPBP1; GTPase [General function prediction only]

    4. XM_017596507.3 → XP_017451996.1  GTP-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K9J3, A6JIT2
      Conserved Domains (1) summary
      COG5258
      Location:1 → 500
      GTPBP1; GTPase [General function prediction only]

    5. XM_006244545.5 → XP_006244607.1  GTP-binding protein 2 isoform X3

      See identical proteins and their annotated locations for XP_006244607.1

      UniProtKB/TrEMBL
      A0A0G2K9J3, A6JIT2
      Conserved Domains (1) summary
      COG5258
      Location:1 → 500
      GTPBP1; GTPase [General function prediction only]

    6. XM_039083824.2 → XP_038939752.1  GTP-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      A6JIT3
      Conserved Domains (3) summary
      cd04165
      Location:23 → 243
      GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2
      cd03694
      Location:258 → 344
      GTPBP_II; Domain II of the GTPBP family of GTP binding proteins
      cd03708
      Location:350 → 437
      GTPBP_III; Domain III of the GP-1 family of GTPases

    RNA

    1. XR_005488932.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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