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    Wls Wnt ligand secretion mediator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362065, updated on 2-Nov-2024

    Summary

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    Symbol
    Wlsprovided by RGD
    Full Name
    Wnt ligand secretion mediatorprovided by RGD
    Primary source
    RGD:735139
    See related
    EnsemblRapid:ENSRNOG00000036816 AllianceGenome:RGD:735139
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr177
    Summary
    Enables mu-type opioid receptor binding activity. Involved in positive regulation of dendrite morphogenesis. Located in dendrite cytoplasm; dendrite membrane; and nucleus. Human ortholog(s) of this gene implicated in Zaki syndrome. Orthologous to human WLS (Wnt ligand secretion mediator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 704.1), Kidney (RPKM 642.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wls in Genome Data Viewer
    Location:
    2q45
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (251590653..251705991)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (248931885..249047248)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (266315036..266431220)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556878 Neighboring gene transfer RNA isoleucine (anticodon AAU) 1 Neighboring gene succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons. Jaremko KM, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2014 Apr 3. PMID 24333843, Free PMC Article
    2. Opiate agonist-induced re-distribution of Wntless, a mu-opioid receptor interacting protein, in rat striatal neurons. Reyes BA, et al. Exp Neurol, 2012 Jan. PMID 22001156, Free PMC Article
    3. Low expression of D2R and Wntless correlates with high motivation for heroin. Tacelosky DM, et al. Behav Neurosci, 2015 Dec. PMID 26501177, Free PMC Article
    4. Wntless in Wnt secretion: molecular, cellular and genetic aspects. Das S, et al. Front Biol (Beijing), 2012 Dec 1. PMID 23439944, Free PMC Article
    5. Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells. Jin J, et al. Dev Dyn, 2010 Sep. PMID 20652957, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results link reduced expression of both the D2R and Wntless to the explicit motivation for heroin rather than to differences in total drug intake per se
      Title: Low expression of D2R and Wntless correlates with high motivation for heroin.
    2. The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt secretion in a variety of embryonic and adult tissue types.
      Title: Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells.
    3. These findings suggest a previously unrecognized role for GPR177 in regulating cellular response to opioid agonist drugs, and could create new avenues of investigation regarding the pharmacotherapy of drug dependence.
      Title: Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Wnt-protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mu-type opioid receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Wnt protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Wnt protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in anterior/posterior axis specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anterior/posterior axis specification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cementum mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocrine pancreas development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hindbrain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mesoderm formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in midbrain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Wnt protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Wnt protein secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in organelle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein wntless homolog
    Names
    EVI
    G protein-coupled receptor 177
    evenness interrupted homolog
    integral membrane protein GPR177
    protein evenness interrupted homolog
    wntless Wnt ligand secretion mediator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085353.1 → NP_001078822.1  protein wntless homolog

      See identical proteins and their annotated locations for NP_001078822.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC062391
      UniProtKB/Swiss-Prot
      Q6P689
      UniProtKB/TrEMBL
      A0A0G2K645
      Conserved Domains (1) summary
      pfam06664
      Location:178 → 496
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    2. NM_199408.3 → NP_955440.1  protein wntless homolog

      See identical proteins and their annotated locations for NP_955440.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q6P689
      UniProtKB/TrEMBL
      A0A0G2K645
      Related
      ENSRNOP00000052120.2, ENSRNOT00000055245.5
      Conserved Domains (1) summary
      pfam06664
      Location:178 → 496
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      251590653..251705991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102736.2 → XP_038958664.1  protein wntless homolog isoform X2

      UniProtKB/TrEMBL
      A0A0G2K645
      Conserved Domains (1) summary
      pfam06664
      Location:159 → 477
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

    2. XM_039102737.2 → XP_038958665.1  protein wntless homolog isoform X1

      UniProtKB/TrEMBL
      A0A0G2K645, A6HWU8
      Conserved Domains (1) summary
      pfam06664
      Location:115 → 433
      MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P689.1 GenPept UniProtKB/Swiss-Prot:Q6P689

    Gene LinkOut

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