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    Uspl1 ubiquitin specific peptidase like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288447, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Uspl1provided by RGD
    Official Full Name
    ubiquitin specific peptidase like 1provided by RGD
    Primary source
    RGD:1310835
    See related
    EnsemblRapid:ENSRNOG00000000909 AllianceGenome:RGD:1310835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310835
    Summary
    Predicted to enable SUMO binding activity and deSUMOylase activity. Predicted to be involved in several processes, including Cajal body organization; protein desumoylation; and snRNA transcription. Predicted to act upstream of or within blastocyst formation. Predicted to be active in Cajal body. Orthologous to human USPL1 (ubiquitin specific peptidase like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 95.3), Adrenal (RPKM 82.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uspl1 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (10859764..10886761, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (5823460..5850470, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (6930018..6957027, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene transfer RNA asparagine (anticodon GUU) 11 Neighboring gene ribosomal protein S19 like 2 Neighboring gene uncharacterized LOC108352413 Neighboring gene small nucleolar RNA SNORA38

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A role for the Cajal-body-associated SUMO isopeptidase USPL1 in snRNA transcription mediated by RNA polymerase II. Hutten S, et al. J Cell Sci, 2014 Mar 1. PMID 24413172, Free PMC Article
    2. Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. Schulz S, et al. EMBO Rep, 2012 Oct. PMID 22878415, Free PMC Article
    3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
    4. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    5. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SUMO binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deSUMOylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cajal body organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Cajal body organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blastocyst formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein desumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Cajal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SUMO-specific isopeptidase USPL1
    Names
    ubiquitin-specific peptidase-like protein 1
    NP_001099376.1
    NP_001185484.1
    XP_006248872.1
    XP_063127186.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105906.2 → NP_001099376.1  SUMO-specific isopeptidase USPL1 isoform 2

      See identical proteins and their annotated locations for NP_001099376.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a split 3' exon, resulting in frame shift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      CB712845, CB787426, CB798160, CO396482, DY309833, EV774129, JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6AFA0, A6K171, D3ZTS4
      Related
      ENSRNOP00000001210.5, ENSRNOT00000001210.9
      Conserved Domains (1) summary
      pfam15499
      Location:217 → 487
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

    2. NM_001198555.1 → NP_001185484.1  SUMO-specific isopeptidase USPL1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      CB712845, CB787426, CB798160, CO396482, DY309833, EV774129, JAXUCZ010000012
      UniProtKB/TrEMBL
      M0R4X8
      Related
      ENSRNOP00000064429.1, ENSRNOT00000072129.4
      Conserved Domains (2) summary
      pfam15499
      Location:215 → 487
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
      pfam15509
      Location:554 → 1067
      DUF4650; Domain of unknown function (DUF4650)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      10859764..10886761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271116.1 → XP_063127186.1  SUMO-specific isopeptidase USPL1 isoform X1

      UniProtKB/TrEMBL
      M0R4X8
      Related
      ENSRNOP00000103801.1, ENSRNOT00000145682.1

    2. XM_006248810.5 → XP_006248872.1  SUMO-specific isopeptidase USPL1 isoform X2

      Related
      ENSRNOP00000090947.2, ENSRNOT00000114472.2
      Conserved Domains (2) summary
      pfam15499
      Location:34 → 304
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
      pfam15509
      Location:371 → 884
      DUF4650; Domain of unknown function (DUF4650)
    Nucleotide Protein Strain
    Heading Accession and Version

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