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    Ctdnep1 CTD nuclear envelope phosphatase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287447, updated on 2-Nov-2024

    Summary

    Official Symbol
    Ctdnep1provided by RGD
    Official Full Name
    CTD nuclear envelope phosphatase 1provided by RGD
    Primary source
    RGD:1310172
    See related
    EnsemblRapid:ENSRNOG00000017352 AllianceGenome:RGD:1310172
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dullard
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in several processes, including positive regulation of triglyceride biosynthetic process; protein dephosphorylation; and protein localization to nucleus. Predicted to act upstream of or within gamete generation; mesoderm development; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and nuclear membrane. Predicted to be part of Nem1-Spo7 phosphatase complex. Orthologous to human CTDNEP1 (CTD nuclear envelope phosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 174.6), Spleen (RPKM 98.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ctdnep1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55203047..55212469)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54704367..54713781)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56590822..56600235)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene claudin 7 Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene GABA type A receptor-associated protein Neighboring gene PHD finger protein 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gamete generation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within gamete generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mesoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear envelope organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nuclear envelope organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear envelope organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of triglyceride biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Nem1-Spo7 phosphatase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Nem1-Spo7 phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Nem1-Spo7 phosphatase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CTD nuclear envelope phosphatase 1
    Names
    serine/threonine-protein phosphatase dullard
    NP_001093964.1
    XP_006246705.2
    XP_006246706.2
    XP_063124715.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100494.1NP_001093964.1  CTD nuclear envelope phosphatase 1

      See identical proteins and their annotated locations for NP_001093964.1

      Status: VALIDATED

      Source sequence(s)
      BC107474, BU671232
      UniProtKB/Swiss-Prot
      Q3B7T6, Q5M952
      UniProtKB/TrEMBL
      A0A8L2QCF2, A6HFZ4
      Related
      ENSRNOP00000096868.2, ENSRNOT00000114193.2
      Conserved Domains (1) summary
      TIGR02251
      Location:61229
      HIF-SF_euk; Dullard-like phosphatase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55203047..55212469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268645.1XP_063124715.1  CTD nuclear envelope phosphatase 1 isoform X3

    2. XM_006246643.5XP_006246705.2  CTD nuclear envelope phosphatase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QCF2
      Conserved Domains (1) summary
      TIGR02251
      Location:93265
      HIF-SF_euk; Dullard-like phosphatase domain
    3. XM_006246644.5XP_006246706.2  CTD nuclear envelope phosphatase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLT1, A0A8L2QCF2
      Related
      ENSRNOP00000023379.6, ENSRNOT00000023379.6
      Conserved Domains (1) summary
      TIGR02251
      Location:93261
      HIF-SF_euk; Dullard-like phosphatase domain