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    Baiap2l1 BAR/IMD domain containing adaptor protein 2 like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304282, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Baiap2l1provided by RGD
    Official Full Name
    BAR/IMD domain containing adaptor protein 2 like 1provided by RGD
    Primary source
    RGD:1308452
    See related
    EnsemblRapid:ENSRNOG00000001007 AllianceGenome:RGD:1308452
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308452
    Summary
    Predicted to enable proline-rich region binding activity. Predicted to be involved in actin crosslink formation; actin filament bundle assembly; and positive regulation of actin filament polymerization. Predicted to be located in actin cytoskeleton and plasma membrane. Predicted to be active in cytosol and nucleoplasm. Orthologous to human BAIAP2L1 (BAR/IMD domain containing adaptor protein 2 like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 76.5), Liver (RPKM 67.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Baiap2l1 in Genome Data Viewer
    Location:
    12p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15364090..15453602)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10250434..10339937)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12226967..12321172)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene ribosomal protein L15 like 1 Neighboring gene ubiquitin-conjugating enzyme E2N, pseudogene 5 Neighboring gene uncharacterized LOC102554669 Neighboring gene brain protein I3 Neighboring gene tectonin beta-propeller repeat containing 1 Neighboring gene basic helix-loop-helix family, member a15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly. Aitio O, et al. Proc Natl Acad Sci U S A, 2010 Dec 14. PMID 21098279, Free PMC Article
    2. Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. Vingadassalom D, et al. Proc Natl Acad Sci U S A, 2009 Apr 21. PMID 19366662, Free PMC Article
    3. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124996

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline-rich region binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proline-rich region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BAR/IMD domain-containing adapter protein 2-like 1; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1
    Names
    BAI1-associated protein 2-like 1
    BAI1-associated protein 2-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034140.1 → NP_001029312.1  BAR/IMD domain-containing adapter protein 2-like 1

      See identical proteins and their annotated locations for NP_001029312.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105815
      UniProtKB/Swiss-Prot
      Q3KR97, Q5FWT2
      UniProtKB/TrEMBL
      A0A8L2QTC2
      Related
      ENSRNOP00000075796.3, ENSRNOT00000092610.3
      Conserved Domains (2) summary
      cd07645
      Location:6 → 231
      I-BAR_IMD_BAIAP2L1; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1
      cd11913
      Location:343 → 400
      SH3_BAIAP2L1; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1, also called Insulin Receptor Tyrosine Kinase Substrate (IRTKS)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      15364090..15453602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598315.3 → XP_017453804.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QTC2
      Related
      ENSRNOP00000057568.6, ENSRNOT00000060843.6

    2. XM_063271253.1 → XP_063127323.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X2

    3. XM_063271254.1 → XP_063127324.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X3

    4. XM_039089346.2 → XP_038945274.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 isoform X3

      Conserved Domains (4) summary
      cd11913
      Location:234 → 291
      SH3_BAIAP2L1; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1, also called Insulin Receptor Tyrosine Kinase Substrate (IRTKS)
      cd21762
      Location:393 → 396
      WH2; actin-binding sequence [structural motif]
      cl12013
      Location:1 → 117
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl41728
      Location:391 → 406
      WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KR97.1 GenPept UniProtKB/Swiss-Prot:Q3KR97

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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