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    Rilpl1 Rab interacting lysosomal protein-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304469, updated on 2-May-2024

    Summary

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    Official Symbol
    Rilpl1provided by RGD
    Official Full Name
    Rab interacting lysosomal protein-like 1provided by RGD
    Primary source
    RGD:1307973
    See related
    Ensembl:ENSRNOG00000001055 AllianceGenome:RGD:1307973
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GOSPEL; RGD1307973
    Summary
    Predicted to enable protein dimerization activity. Involved in regulation of neuron death. Located in cytosol. Orthologous to human RILPL1 (Rab interacting lysosomal protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 462.3), Muscle (RPKM 314.3) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rilpl1 in Genome Data Viewer
    Location:
    12q15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37732847..37770659)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32071870..32109687)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37490320..37528393)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 55 Neighboring gene transmembrane p24 trafficking protein 2 Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 35 Neighboring gene Rab interacting lysosomal protein-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content. Schaub JR, et al. Mol Biol Cell, 2013 Feb. PMID 23264467, Free PMC Article
    2. GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Sen N, et al. Neuron, 2009 Jul 16. PMID 19607794, Free PMC Article
    3. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nitric oxide mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport from ciliary membrane to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport from ciliary membrane to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport from ciliary membrane to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RILP-like protein 1
    Names
    GAPDH's competitor of SIAH1 protein enhances life
    rab-interacting lysosomal-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191665.1 → NP_001178594.1  RILP-like protein 1

      See identical proteins and their annotated locations for NP_001178594.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      D3ZUQ0
      UniProtKB/TrEMBL
      A0A8L2PZW4
      Related
      ENSRNOP00000001401.6, ENSRNOT00000001401.8
      Conserved Domains (3) summary
      TIGR02169
      Location:76 → 322
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam09744
      Location:27 → 174
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11461
      Location:299 → 351
      RILP; Rab interacting lysosomal protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      37732847..37770659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249296.5 → XP_006249358.1  RILP-like protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZUH1
      Related
      ENSRNOP00000082699.1
      Conserved Domains (2) summary
      pfam09744
      Location:28 → 174
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11461
      Location:299 → 351
      RILP; Rab interacting lysosomal protein

    2. XM_006249294.3 → XP_006249356.1  RILP-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006249356.1

      UniProtKB/TrEMBL
      A0A8L2PZW4, A6J0Z1
      Conserved Domains (2) summary
      pfam09744
      Location:28 → 174
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11461
      Location:299 → 351
      RILP; Rab interacting lysosomal protein

    3. XM_006249295.4 → XP_006249357.1  RILP-like protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZUH1
      Conserved Domains (2) summary
      pfam09744
      Location:28 → 174
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11461
      Location:299 → 351
      RILP; Rab interacting lysosomal protein

    4. XM_039089435.2 → XP_038945363.1  RILP-like protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZUH1
      Conserved Domains (3) summary
      TIGR02169
      Location:76 → 322
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam09744
      Location:27 → 174
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11461
      Location:299 → 351
      RILP; Rab interacting lysosomal protein

    5. XM_039089436.2 → XP_038945364.1  RILP-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZUH1
      Conserved Domains (3) summary
      TIGR02169
      Location:76 → 322
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam09744
      Location:27 → 174
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11461
      Location:299 → 351
      RILP; Rab interacting lysosomal protein

    6. XM_039089439.2 → XP_038945367.1  RILP-like protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZUH1
      Related
      ENSRNOP00000082089.1
      Conserved Domains (3) summary
      TIGR02169
      Location:76 → 322
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam09744
      Location:27 → 174
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11461
      Location:299 → 351
      RILP; Rab interacting lysosomal protein

    7. XM_039089437.2 → XP_038945365.1  RILP-like protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K2U5, A0A8I5ZUH1
      Related
      ENSRNOP00000072380.2
      Conserved Domains (3) summary
      TIGR02169
      Location:76 → 322
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam09744
      Location:27 → 174
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11461
      Location:299 → 351
      RILP; Rab interacting lysosomal protein

    8. XM_039089438.2 → XP_038945366.1  RILP-like protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZUH1
      Conserved Domains (3) summary
      TIGR02169
      Location:76 → 322
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam09744
      Location:27 → 174
      Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
      pfam11461
      Location:299 → 351
      RILP; Rab interacting lysosomal protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZUQ0.1 GenPept UniProtKB/Swiss-Prot:D3ZUQ0

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