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    Tsr2 TSR2, ribosome maturation factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317418, updated on 2-Nov-2024

    Summary

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    Symbol
    Tsr2provided by RGD
    Full Name
    TSR2, ribosome maturation factorprovided by RGD
    Primary source
    RGD:1562416
    See related
    EnsemblRapid:ENSRNOG00000064917 AllianceGenome:RGD:1562416
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562416
    Summary
    Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 14 with mandibulofacial dysostosis. Orthologous to human TSR2 (TSR2 ribosome maturation factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 180.5), Adrenal (RPKM 96.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tsr2 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (23507141..23515711, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (20064102..20072673, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (20141406..20146082, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1, pseudogene 13 Neighboring gene serine and arginine rich splicing factor 5, pseudogene 1 Neighboring gene FYVE, RhoGEF and PH domain containing 1 Neighboring gene ribosomal protein S12, pseudogene Neighboring gene WNK lysine deficient protein kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pre-rRNA-processing protein TSR2 homolog
    Names
    TSR2, 20S rRNA accumulation, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115027.1 → NP_001108499.1  pre-rRNA-processing protein TSR2 homolog

      See identical proteins and their annotated locations for NP_001108499.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474063
      UniProtKB/TrEMBL
      A6KL99, B0BN59
      Related
      ENSRNOP00000085935.2, ENSRNOT00000098819.2
      Conserved Domains (1) summary
      pfam10273
      Location:13 → 92
      WGG; Pre-rRNA-processing protein TSR2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      23507141..23515711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099803.2 → XP_038955731.1  pre-rRNA-processing protein TSR2 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZLR7, B0BN59
      Related
      ENSRNOP00000078813.1, ENSRNOT00000118302.2
      Conserved Domains (1) summary
      pfam10273
      Location:13 → 127
      WGG; Pre-rRNA-processing protein TSR2
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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