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    Agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362300, updated on 2-Nov-2024

    Summary

    Official Symbol
    Agap3provided by RGD
    Official Full Name
    ArfGAP with GTPase domain, ankyrin repeat and PH domain 3provided by RGD
    Primary source
    RGD:1310751
    See related
    EnsemblRapid:ENSRNOG00000012764 AllianceGenome:RGD:1310751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Centg3
    Summary
    Predicted to enable GTPase activator activity; GTPase activity; and polyubiquitin modification-dependent protein binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 71.5), Lung (RPKM 55.2) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Agap3 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11567191..11617610, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10674746..10724848, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7202330..7253386, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 10 Neighboring gene gastrulation brain homeobox 1 Neighboring gene uncharacterized LOC134486542 Neighboring gene transmembrane and ubiquitin-like domain containing 1 Neighboring gene Fas-activated serine/threonine kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
    Names
    centaurin, gamma 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398853.1NP_001385782.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      Related
      ENSRNOP00000070947.3, ENSRNOT00000087120.3
      Conserved Domains (5) summary
      cd04103
      Location:127284
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      cd01250
      Location:400542
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      sd00045
      Location:686716
      ANK; ANK repeat [structural motif]
      cd08855
      Location:558667
      ArfGap_AGAP3; ArfGAP with GTPase domain, ANK repeat and PH domain 3
      pfam12796
      Location:686776
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      11567191..11617610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235941.5XP_006236003.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K2D4, U6A022
      Related
      ENSRNOP00000072199.2, ENSRNOT00000084777.3
      Conserved Domains (8) summary
      cd04103
      Location:127284
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      smart00010
      Location:125290
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd00204
      Location:787876
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01250
      Location:400643
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      pfam00169
      Location:403464
      PH; PH domain
      pfam01412
      Location:671776
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:787877
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:787817
      ANK; ANK repeat [structural motif]
    2. XM_008762650.4XP_008760872.2  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X12

      UniProtKB/TrEMBL
      U6A022
    3. XM_006235938.5XP_006236000.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1

      Conserved Domains (8) summary
      cd04103
      Location:311468
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      smart00010
      Location:309474
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd00204
      Location:9711060
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01250
      Location:584827
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      pfam00169
      Location:587648
      PH; PH domain
      pfam01412
      Location:855960
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:9711061
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:9711001
      ANK; ANK repeat [structural motif]
    4. XM_006235940.5XP_006236002.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y9H3
      Conserved Domains (8) summary
      cd04103
      Location:311468
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      smart00010
      Location:309474
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd00204
      Location:870959
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01250
      Location:584726
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      pfam00169
      Location:587721
      PH; PH domain
      pfam01412
      Location:754859
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:870960
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:870900
      ANK; ANK repeat [structural motif]
    5. XM_006235939.5XP_006236001.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X2

      Conserved Domains (8) summary
      cd04103
      Location:311468
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      smart00010
      Location:309474
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cd00204
      Location:9251014
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01250
      Location:584781
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      pfam00169
      Location:587648
      PH; PH domain
      pfam01412
      Location:809914
      ArfGap; Putative GTPase activating protein for Arf
      pfam12796
      Location:9251015
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:925955
      ANK; ANK repeat [structural motif]
    6. XM_039107750.2XP_038963678.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X10

      UniProtKB/TrEMBL
      A6K545
      Conserved Domains (4) summary
      cd01250
      Location:55197
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      sd00045
      Location:341371
      ANK; ANK repeat [structural motif]
      cd08855
      Location:213322
      ArfGap_AGAP3; ArfGAP with GTPase domain, ANK repeat and PH domain 3
      pfam12796
      Location:341431
      Ank_2; Ankyrin repeats (3 copies)
    7. XM_039107748.2XP_038963676.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X8

      UniProtKB/TrEMBL
      A6K545
      Conserved Domains (5) summary
      PHA03247
      Location:122252
      PHA03247; large tegument protein UL36; Provisional
      cd01250
      Location:55298
      PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
      sd00045
      Location:442472
      ANK; ANK repeat [structural motif]
      cl28907
      Location:314423
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
      pfam12796
      Location:442532
      Ank_2; Ankyrin repeats (3 copies)
    8. XM_039107749.2XP_038963677.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X9

      UniProtKB/TrEMBL
      A6K545
      Conserved Domains (4) summary
      sd00045
      Location:344374
      ANK; ANK repeat [structural motif]
      cl28907
      Location:216325
      ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
      pfam12796
      Location:344434
      Ank_2; Ankyrin repeats (3 copies)
      cl17171
      Location:1200
      PH-like; Pleckstrin homology-like domain
    9. XM_063286226.1XP_063142296.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X5

    10. XM_006235943.5XP_006236005.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X11

      UniProtKB/TrEMBL
      A0A0G2JZ83
      Related
      ENSRNOP00000100965.1, ENSRNOT00000171340.1
      Conserved Domains (2) summary
      cd04103
      Location:127284
      Centaurin_gamma; Centaurin gamma (CENTG) GTPase
      smart00010
      Location:125290
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    11. XM_017592682.3XP_017448171.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X7

      UniProtKB/TrEMBL
      G3V9Z5
      Related
      ENSRNOP00000063846.2, ENSRNOT00000064386.4
    12. XM_063286227.1XP_063142297.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108616.1: Suppressed sequence

      Description
      NM_001108616.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.