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    Klf3 KLF transcription factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114845, updated on 28-Oct-2024

    Summary

    Official Symbol
    Klf3provided by RGD
    Official Full Name
    KLF transcription factor 3provided by RGD
    Primary source
    RGD:1593290
    See related
    EnsemblRapid:ENSRNOG00000002163 AllianceGenome:RGD:1593290
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bklf; Tef-2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to peptide. Predicted to be located in nucleoplasm. Orthologous to human KLF3 (KLF transcription factor 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Thymus (RPKM 161.3), Spleen (RPKM 105.5) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Klf3 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43828387..43859418, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (43474767..43505801, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (45142769..45173753, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene toll-like receptor 1 Neighboring gene toll-like receptor 10 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC103692863

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cellular response to peptide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    Krueppel-like factor 3
    Names
    Basic Kruppel- like factor
    Kruppel like factor 3
    Kruppel-like factor 3 (basic)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105742.3NP_001099212.1  Krueppel-like factor 3

      See identical proteins and their annotated locations for NP_001099212.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6JDG0, A6JDG1, D4A4V3
      Related
      ENSRNOP00000002960.4, ENSRNOT00000002960.8
      Conserved Domains (4) summary
      COG5048
      Location:169331
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:259283
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305330
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001433852.1NP_001420781.1  Krueppel-like factor 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      43828387..43859418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770134.3XP_008768356.1  Krueppel-like factor 3 isoform X1

      UniProtKB/TrEMBL
      A6JDG0, A6JDG1, D4A4V3
      Conserved Domains (4) summary
      COG5048
      Location:169331
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:259283
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305330
      zf-H2C2_2; Zinc-finger double domain
    2. XM_006250995.5XP_006251057.1  Krueppel-like factor 3 isoform X1

      See identical proteins and their annotated locations for XP_006251057.1

      UniProtKB/TrEMBL
      A6JDG0, A6JDG1, D4A4V3
      Conserved Domains (4) summary
      COG5048
      Location:169331
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:259283
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:305330
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_005492873.2 RNA Sequence