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    Asb5 ankyrin repeat and SOCS box-containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361187, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Asb5provided by RGD
    Official Full Name
    ankyrin repeat and SOCS box-containing 5provided by RGD
    Primary source
    RGD:1565973
    See related
    EnsemblRapid:ENSRNOG00000042630 AllianceGenome:RGD:1565973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in positive regulation of protein catabolic process and protein ubiquitination. Predicted to be integral component of membrane. Orthologous to human ASB5 (ankyrin repeat and SOCS box containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 160.4), Heart (RPKM 11.9) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asb5 in Genome Data Viewer
    Location:
    16p11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (43970940..44038318, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (37237869..37305207, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (39985233..40050663, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 17 Neighboring gene spermatogenesis associated 4 Neighboring gene signal peptidase complex subunit 3 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114420

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044247.2 → NP_001037712.1  ankyrin repeat and SOCS box protein 5 isoform 1

      See identical proteins and their annotated locations for NP_001037712.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6A894, D4A0S9, Q4KLY9
      Conserved Domains (5) summary
      cd00204
      Location:71 → 188
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03724
      Location:273 → 314
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      pfam12796
      Location:74 → 165
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:218 → 267
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:71 → 100
      ANK; ANK repeat [structural motif]

    2. NM_001399413.1 → NP_001386342.1  ankyrin repeat and SOCS box protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8J8XZ77, A6JPH2
      Related
      ENSRNOP00000061114.3, ENSRNOT00000066639.5
      Conserved Domains (3) summary
      PHA02876
      Location:72 → 288
      PHA02876; ankyrin repeat protein; Provisional
      cd03724
      Location:288 → 329
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:71 → 100
      ANK; ANK repeat [structural motif]

    3. NM_001399414.1 → NP_001386343.1  ankyrin repeat and SOCS box protein 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      Related
      ENSRNOP00000088645.2, ENSRNOT00000103090.2
      Conserved Domains (3) summary
      cd03724
      Location:243 → 284
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:71 → 100
      ANK; ANK repeat [structural motif]
      cl39094
      Location:73 → 244
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      43970940..44038318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275582.1 → XP_063131652.1  ankyrin repeat and SOCS box protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8J8XZ77, A6JPH2

    2. XM_017600190.3 → XP_017455679.1  ankyrin repeat and SOCS box protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A894, A0A8J8XZ77, A6JPH2
      Conserved Domains (3) summary
      PHA02876
      Location:72 → 288
      PHA02876; ankyrin repeat protein; Provisional
      cd03724
      Location:288 → 329
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:71 → 100
      ANK; ANK repeat [structural motif]

    3. XM_039094701.2 → XP_038950629.1  ankyrin repeat and SOCS box protein 5 isoform X6

      Conserved Domains (3) summary
      PHA02876
      Location:19 → 235
      PHA02876; ankyrin repeat protein; Provisional
      sd00045
      Location:18 → 47
      ANK; ANK repeat [structural motif]
      cl02533
      Location:235 → 276
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    4. XM_039094698.2 → XP_038950626.1  ankyrin repeat and SOCS box protein 5 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A894, A0A8I6GE39
      Related
      ENSRNOP00000086492.1, ENSRNOT00000116663.2
      Conserved Domains (3) summary
      cd03724
      Location:265 → 306
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:48 → 77
      ANK; ANK repeat [structural motif]
      cl39094
      Location:50 → 266
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_008771248.4 → XP_008769470.1  ankyrin repeat and SOCS box protein 5 isoform X5

      UniProtKB/TrEMBL
      A0A0G2K854
      Related
      ENSRNOP00000074476.2, ENSRNOT00000089665.3
      Conserved Domains (4) summary
      cd00204
      Location:26 → 143
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03724
      Location:243 → 284
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      pfam12796
      Location:29 → 120
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:26 → 55
      ANK; ANK repeat [structural motif]

    6. XM_039094699.2 → XP_038950627.1  ankyrin repeat and SOCS box protein 5 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A894
      Related
      ENSRNOP00000103447.1, ENSRNOT00000162968.1
      Conserved Domains (3) summary
      cd03724
      Location:258 → 299
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:41 → 70
      ANK; ANK repeat [structural motif]
      cl39094
      Location:26 → 259
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_039094697.2 → XP_038950625.1  ankyrin repeat and SOCS box protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A894
      Conserved Domains (3) summary
      cd03724
      Location:266 → 307
      SOCS_ASB5; SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS ...
      sd00045
      Location:49 → 78
      ANK; ANK repeat [structural motif]
      cl39094
      Location:34 → 267
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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