Wwc1 WW and C2 domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wwc1provided by RGD
Official Full Name: WW and C2 domain containing 1provided by RGD
Primary source: RGD:1308329
See related: EnsemblRapid:ENSRNOG00000008065 AllianceGenome:RGD:1308329
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308329
Summary: Enables protein-macromolecule adaptor activity. Involved in cell migration. Part of protein-containing complex. Is active in postsynaptic density, intracellular component. Orthologous to human WWC1 (WW and C2 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 234.0), Lung (RPKM 95.9) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (20804173..20958437, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (20300735..20454393, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (20662996..20818500, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WWC1 upregulation accelerates hyperuricemia by reduction in renal uric acid excretion through Hippo signaling pathway.
Title: WWC1 upregulation accelerates hyperuricemia by reduction in renal uric acid excretion through Hippo signaling pathway.
Results provide the first evidence that KIBRA as well as PKMzeta is closely related to reference memory but not working memory in rats
Title: Both PKMζ and KIBRA are closely related to reference memory but not working memory in a T-maze task in rats.
KIBRA levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMzeta
Title: KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ.

Submit: New GeneRIF Correction

General gene information

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Markers

D10Got36 (e-PCR)
- UniSTS:115509

D10Mco52 (e-PCR)
- UniSTS:240231

RH139729 (e-PCR)
- UniSTS:221813

d10rat216 (e-PCR)
- UniSTS:120693

RH141360 (e-PCR)
- UniSTS:223356

BI282183 (e-PCR)
- UniSTS:249758

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of hippo signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein KIBRA

Names: WW, C2 and coiled-coil domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.