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    Kcnt1 potassium sodium-activated channel subfamily T member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60444, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kcnt1provided by RGD
    Official Full Name
    potassium sodium-activated channel subfamily T member 1provided by RGD
    Primary source
    RGD:621106
    See related
    EnsemblRapid:ENSRNOG00000017283 AllianceGenome:RGD:621106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slack; rSlo2
    Summary
    Enables chloride-activated potassium channel activity and intracellular sodium-activated potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5 and developmental and epileptic encephalopathy 14. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 118.1), Brain (RPKM 100.3) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnt1 in Genome Data Viewer
    Location:
    3p13
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (29081071..29136902)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8682964..8736615)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (3310641..3366558)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene lipocalin 9 Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 1 Neighboring gene calmodulin regulated spectrin-associated protein 1 Neighboring gene ribosomal protein L8, pseudogene 7 Neighboring gene PIH1 domain containing 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of Sodium- and Chloride-Sensitive Sites in the Slack Channel. Xu J, et al. J Neurosci, 2023 Apr 12. PMID 36898835, Free PMC Article
    2. The Phe932Ile mutation in KCNT1 channels associated with severe epilepsy, delayed myelination and leukoencephalopathy produces a loss-of-function channel phenotype. Evely KM, et al. Neuroscience, 2017 May 20. PMID 28366665, Free PMC Article
    3. Slack sodium-activated potassium channel membrane expression requires p38 mitogen-activated protein kinase phosphorylation. Gururaj S, et al. Neuropharmacology, 2016 Apr. PMID 26721627, Free PMC Article
    4. cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel. Nuwer MO, et al. Neuropharmacology, 2009 Sep. PMID 19540251
    5. The sodium-activated potassium channel Slack is modulated by hypercapnia and acidosis. Ruffin VA, et al. Neuroscience, 2008 Jan 24. PMID 18082331, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal Cell Excitability in Working Memory Circuits.
      Title: Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal Cell Excitability in Working Memory Circuits.
    2. Identification of Sodium- and Chloride-Sensitive Sites in the Slack Channel.
      Title: Identification of Sodium- and Chloride-Sensitive Sites in the Slack Channel.
    3. Magi-1 bound to sequence like a calcium-activated potassium channel sodium-activated (Slack) potassium channels, demonstrating macrocomplexing with NaV1.8 channels.
      Title: Magi-1 scaffolds Na(V)1.8 and Slack K(Na) channels in dorsal root ganglion neurons regulating excitability and pain.
    4. characterized an analogous mutation in the rat Slack channel and unexpectedly found this mutation to produce a loss-of-function phenotype
      Title: The Phe932Ile mutation in KCNT1 channels associated with severe epilepsy, delayed myelination and leukoencephalopathy produces a loss-of-function channel phenotype.
    5. mRNA of aquaporin 1 was co-expressed in Xenopus oocytes with homomeric or heteromeric Slick and Slack alpha-subunits. Hypotonic or hypertonic buffers caused changes in current. The heteromeric channel had a characteristic graded sensitivity to small and fast changes in cell volume. This the cell volume sensitivity is dependent on the number of volume sensitive Slick alpha-subunits in the tetrameric channels.
      Title: Heteromeric Slick/Slack K+ channels show graded sensitivity to cell volume changes.
    6. Results show that p38 MAPK is an obligate regulator of Slack channel function via the trafficking of channels into the membrane. The present study identifies Slack KNa channels as p38 MAPK substrates.
      Title: Slack sodium-activated potassium channel membrane expression requires p38 mitogen-activated protein kinase phosphorylation.
    7. Slick channels, in contrast to the similar Slack channels, are the only high-conductance K+ channels strongly sensitive to small changes in cell volume.
      Title: Cell volume changes regulate slick (Slo2.1), but not slack (Slo2.2) K+ channels.
    8. phosphorylation by protein kinase A does not acutely modulate the function and gating activation kinetics of Slack channels
      Title: cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel.
    9. Heteromer formation requires the N-terminal domain of Slack-B, one of the alternative splice variants of the Slack channel.
      Title: The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels.
    10. We conclude that Slack and Slick K(Na) channels are required for depolarizing afterpotential of medium diameter rat dorsal root ganglion neurons
      Title: Slack and Slick KNa channels are required for the depolarizing afterpotential of acutely isolated, medium diameter rat dorsal root ganglion neurons.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chloride-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables intracellular sodium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellular sodium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    potassium channel subfamily T member 1
    Names
    potassium channel subunit (Slack)
    potassium channel, sodium-activated subfamily T, member 1
    potassium channel, subfamily T, member 1
    sequence like a calcium-activated potassium channel subunit

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413123.1 → NP_001400052.1  potassium channel subfamily T member 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      Related
      ENSRNOP00000103835.1, ENSRNOT00000130387.1

    2. NM_021853.2 → NP_068625.2  potassium channel subfamily T member 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      Related
      ENSRNOP00000089937.1, ENSRNOT00000104747.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      29081071..29136902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233704.5 → XP_006233766.1  potassium channel subfamily T member 1 isoform X8

      UniProtKB/TrEMBL
      A6JTB4
      Conserved Domains (2) summary
      pfam03493
      Location:450 → 545
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:224 → 297
      Ion_trans_2; Ion channel

    2. XM_008761624.4 → XP_008759846.1  potassium channel subfamily T member 1 isoform X13

      UniProtKB/TrEMBL
      A0A8I6ALJ8, A6JTB4
      Related
      ENSRNOP00000096324.1, ENSRNOT00000110074.2
      Conserved Domains (2) summary
      pfam03493
      Location:464 → 559
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:238 → 311
      Ion_trans_2; Ion channel

    3. XM_006233707.5 → XP_006233769.1  potassium channel subfamily T member 1 isoform X10

      UniProtKB/TrEMBL
      A6JTB4, D3ZNI9
      Related
      ENSRNOP00000058487.3, ENSRNOT00000061773.5
      Conserved Domains (2) summary
      pfam03493
      Location:450 → 545
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:224 → 297
      Ion_trans_2; Ion channel

    4. XM_006233706.5 → XP_006233768.1  potassium channel subfamily T member 1 isoform X9

      UniProtKB/TrEMBL
      A6JTB5
      Conserved Domains (2) summary
      pfam03493
      Location:484 → 579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:258 → 331
      Ion_trans_2; Ion channel

    5. XM_063284465.1 → XP_063140535.1  potassium channel subfamily T member 1 isoform X11

    6. XM_006233698.5 → XP_006233760.1  potassium channel subfamily T member 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5D6C6, Q9Z258
      Conserved Domains (2) summary
      pfam03493
      Location:484 → 579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:258 → 331
      Ion_trans_2; Ion channel

    7. XM_006233697.5 → XP_006233759.1  potassium channel subfamily T member 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5D6C6, Q9Z258
      Conserved Domains (2) summary
      pfam03493
      Location:484 → 579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:258 → 331
      Ion_trans_2; Ion channel

    8. XM_006233701.5 → XP_006233763.1  potassium channel subfamily T member 1 isoform X5

      UniProtKB/Swiss-Prot
      Q5D6C6, Q9Z258
      Conserved Domains (2) summary
      pfam03493
      Location:484 → 579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:258 → 331
      Ion_trans_2; Ion channel

    9. XM_006233700.5 → XP_006233762.1  potassium channel subfamily T member 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A9R0
      Conserved Domains (2) summary
      pfam03493
      Location:470 → 565
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:244 → 317
      Ion_trans_2; Ion channel

    10. XM_006233699.5 → XP_006233761.1  potassium channel subfamily T member 1 isoform X3

      UniProtKB/Swiss-Prot
      Q5D6C6, Q9Z258
      UniProtKB/TrEMBL
      F1LSG1
      Related
      ENSRNOP00000023542.6, ENSRNOT00000023542.7
      Conserved Domains (2) summary
      pfam03493
      Location:484 → 579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:258 → 331
      Ion_trans_2; Ion channel

    11. XM_006233703.5 → XP_006233765.1  potassium channel subfamily T member 1 isoform X7

      UniProtKB/Swiss-Prot
      Q5D6C6, Q9Z258
      Conserved Domains (2) summary
      pfam03493
      Location:484 → 579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:258 → 331
      Ion_trans_2; Ion channel

    12. XM_006233702.5 → XP_006233764.1  potassium channel subfamily T member 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A9R0
      Conserved Domains (2) summary
      pfam03493
      Location:470 → 565
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:244 → 317
      Ion_trans_2; Ion channel

    13. XM_039105771.2 → XP_038961699.1  potassium channel subfamily T member 1 isoform X12

      Conserved Domains (1) summary
      pfam03493
      Location:50 → 152
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    RNA

    1. XR_005501975.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z258.1 GenPept UniProtKB/Swiss-Prot:Q9Z258

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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