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    Stim2 stromal interaction molecule 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117087, updated on 9-Jul-2024

    Summary

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    Official Symbol
    Stim2provided by RGD
    Official Full Name
    stromal interaction molecule 2provided by RGD
    Primary source
    RGD:1304641
    See related
    Ensembl:ENSRNOG00000002956 AllianceGenome:RGD:1304641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium channel regulator activity. Involved in activation of store-operated calcium channel activity. Located in plasma membrane. Orthologous to human STIM2 (stromal interaction molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 67.9), Brain (RPKM 53.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stim2 in Genome Data Viewer
    Location:
    14q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (61091550..61217281, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (56878428..57004405, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (59198180..59323947, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23A like 5 Neighboring gene cofilin 1, pseudogene 6 Neighboring gene U2 spliceosomal RNA Neighboring gene TBC1 domain family, member 19 Neighboring gene cholecystokinin A receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low Energy Availability Induced by 3-NP in Male Rats. Iranipour N, et al. Neurotox Res, 2021 Oct. PMID 34173958
    2. Inhibition of store-operated calcium entry by sub-lethal levels of proteasome inhibition is associated with STIM1/STIM2 degradation. Kuang XL, et al. Cell Calcium, 2016 Apr. PMID 26960935
    3. STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs. Garcia-Alvarez G, et al. Mol Biol Cell, 2015 Mar 15. PMID 25609091, Free PMC Article
    4. STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels. Brandman O, et al. Cell, 2007 Dec 28. PMID 18160041, Free PMC Article
    5. STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons. Gruszczynska-Biegala J, et al. Cells, 2020 Jan 9. PMID 31936514, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STIM2 variants regulate Orai1/TRPC1/TRPC4-mediated store-operated Ca[2+] entry and mitochondrial Ca[2+] homeostasis in cardiomyocytes.
      Title: STIM2 variants regulate Orai1/TRPC1/TRPC4-mediated store-operated Ca(2+) entry and mitochondrial Ca(2+) homeostasis in cardiomyocytes.
    2. STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low Energy Availability Induced by 3-NP in Male Rats.
      Title: STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low Energy Availability Induced by 3-NP in Male Rats.
    3. STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
      Title: STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
    4. conclude that sub-lethal levels of proteasome inhibition reduce store-operated calcium entry and promote autophagy-mediated degradation of STIM1/2
      Title: Inhibition of store-operated calcium entry by sub-lethal levels of proteasome inhibition is associated with STIM1/STIM2 degradation.
    5. STIM2 promotes cAMP-dependent surface delivery of GluA1 through combined effects on exocytosis and endocytosis.
      Title: STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs.
    6. TRPC2, by regulating STIM2, PKC expression, and SERCA activity, regulates calcium homeostasis in thyroid cells.
      Title: Canonical transient receptor potential channel 2 (TRPC2) as a major regulator of calcium homeostasis in rat thyroid FRTL-5 cells: importance of protein kinase C δ (PKCδ) and stromal interaction molecule 2 (STIM2).
    7. Stim1 and Stim2 were increased in brains of chronic epileptic rodents and strongly expressed in hippocampal specimens from medial temporal lobe epilepsy patients.
      Title: Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy.
    8. STIM1 mainly activates store-operated calcium entry, whereas STIM2 regulates resting Ca(2+) levels in the endoplasmic reticulum and Ca(2+) leakage with the additional involvement of STIM1.
      Title: Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables store-operated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    stromal interaction molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105750.2 → NP_001099220.2  stromal interaction molecule 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6IJF3, D4A5X1
      Related
      ENSRNOP00000004006.7, ENSRNOT00000004006.9
      Conserved Domains (3) summary
      cd09574
      Location:132 → 205
      SAM_STIM2; SAM domain of STIM2 subfamily proteins
      smart00454
      Location:133 → 197
      SAM; Sterile alpha motif
      pfam16533
      Location:348 → 445
      SOAR; STIM1 Orai1-activating region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      61091550..61217281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091560.2 → XP_038947488.1  stromal interaction molecule 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A6S4, A6IJF3, D4A5X1
      Related
      ENSRNOP00000087921.1, ENSRNOT00000119766.2
      Conserved Domains (3) summary
      cd09574
      Location:198 → 271
      SAM_STIM2; SAM domain of STIM2 subfamily proteins
      COG1196
      Location:304 → 513
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam16533
      Location:414 → 519
      SOAR; STIM1 Orai1-activating region

    2. XM_039091561.2 → XP_038947489.1  stromal interaction molecule 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AK33
      Related
      ENSRNOP00000089061.1, ENSRNOT00000113845.2
      Conserved Domains (3) summary
      cd09574
      Location:103 → 176
      SAM_STIM2; SAM domain of STIM2 subfamily proteins
      COG1196
      Location:209 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam16533
      Location:319 → 424
      SOAR; STIM1 Orai1-activating region

    3. XM_039091563.2 → XP_038947491.1  stromal interaction molecule 2 isoform X5

      Conserved Domains (3) summary
      COG1196
      Location:60 → 269
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam16533
      Location:170 → 275
      SOAR; STIM1 Orai1-activating region
      cl15755
      Location:1 → 27
      SAM_superfamily; SAM (Sterile alpha motif )

    4. XM_039091562.2 → XP_038947490.1  stromal interaction molecule 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AK33
      Conserved Domains (3) summary
      cd09574
      Location:13 → 85
      SAM_STIM2; SAM domain of STIM2 subfamily proteins
      COG1196
      Location:118 → 327
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam16533
      Location:228 → 333
      SOAR; STIM1 Orai1-activating region

    5. XM_063272807.1 → XP_063128877.1  stromal interaction molecule 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AK33
    Nucleotide Protein Strain
    Heading Accession and Version

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