Dguok deoxyguanosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dguokprovided by RGD
Official Full Name: deoxyguanosine kinaseprovided by RGD
Primary source: RGD:1304799
See related: EnsemblRapid:ENSRNOG00000011617 AllianceGenome:RGD:1304799
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable deoxyguanosine kinase activity. Involved in mitochondrial ATP synthesis coupled electron transport and negative regulation of neuron projection development. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Used to study mitochondrial DNA depletion syndrome 3. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; and mitochondrial metabolism disease. Orthologous to human DGUOK (deoxyguanosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 144.6), Adrenal (RPKM 117.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (117544784..117572414, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (115987101..116014733, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (115180433..115208061, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The nucleotide prodrug CERC-913 improves mtDNA content in primary hepatocytes from DGUOK-deficient rats.
Title: The nucleotide prodrug CERC-913 improves mtDNA content in primary hepatocytes from DGUOK-deficient rats.
The goals of this work are to characterize the DGUOK rat in terms of mitochondrial dysfunction and pathological outcome, and to evaluate EPR as a new and additional technique in an integrated characterization of mitochondrial disease .
Title: Potentially diagnostic electron paramagnetic resonance spectra elucidate the underlying mechanism of mitochondrial dysfunction in the deoxyguanosine kinase deficient rat model of a genetic mitochondrial DNA depletion syndrome.

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General gene information

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Markers

RH141839 (e-PCR)
- UniSTS:223831

RH134697 (e-PCR)
- UniSTS:217975

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables deoxyguanosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxyguanosine kinase activity	ISO Inferred from Sequence Orthology more info
enables deoxynucleoside kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in dAMP salvage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dGTP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within deoxyribonucleoside monophosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ATP synthesis coupled electron transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in purine deoxyribonucleoside metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: deoxyguanosine kinase, mitochondrial

NP_001100072.1

EC 2.7.1.113

XP_006236797.1

EC 2.7.1.113

XP_006236798.1

EC 2.7.1.113

XP_006236799.1

EC 2.7.1.113

XP_008761278.1

EC 2.7.1.113

XP_008761279.1

EC 2.7.1.113

XP_038963265.1

EC 2.7.1.113

XP_038963266.1

EC 2.7.1.113

XP_038963268.1

EC 2.7.1.113

XP_038963269.1

EC 2.7.1.113

XP_063141870.1

EC 2.7.1.113

XP_063141871.1

EC 2.7.1.113

XP_063141872.1

EC 2.7.1.113

XP_063141873.1

EC 2.7.1.113

XP_063141874.1

EC 2.7.1.113

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106602.1 → NP_001100072.1 deoxyguanosine kinase, mitochondrial

See identical proteins and their annotated locations for NP_001100072.1

Status: PROVISIONAL

Source sequence(s)

CH473957

UniProtKB/TrEMBL

A6IAM4, A6IAM6, D3ZDE4

Conserved Domains (1) summary

pfam01712
Location:41 → 269

dNK; Deoxynucleoside kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

117544784..117572414 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107337.2 → XP_038963265.1 deoxyguanosine kinase, mitochondrial isoform X2

Related

ENSRNOP00000062535.2, ENSRNOT00000066678.4

Conserved Domains (1) summary

pfam01712
Location:41 → 325

dNK; Deoxynucleoside kinase
XM_006236737.5 → XP_006236799.1 deoxyguanosine kinase, mitochondrial isoform X6

See identical proteins and their annotated locations for XP_006236799.1

UniProtKB/TrEMBL

A6IAM5, A6IAM6

Conserved Domains (1) summary

pfam01712
Location:41 → 275

dNK; Deoxynucleoside kinase
XM_008763057.4 → XP_008761279.1 deoxyguanosine kinase, mitochondrial isoform X4

UniProtKB/TrEMBL

A0A8I5ZV32

Related

ENSRNOP00000105366.1, ENSRNOT00000135424.1

Conserved Domains (1) summary

pfam01712
Location:41 → 270

dNK; Deoxynucleoside kinase
XM_063285800.1 → XP_063141870.1 deoxyguanosine kinase, mitochondrial isoform X7
XM_006236735.5 → XP_006236797.1 deoxyguanosine kinase, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A0G2K478

Related

ENSRNOP00000072937.2, ENSRNOT00000084388.3

Conserved Domains (1) summary

pfam01712
Location:41 → 331

dNK; Deoxynucleoside kinase
XM_008763056.4 → XP_008761278.1 deoxyguanosine kinase, mitochondrial isoform X1

Conserved Domains (1) summary

pfam01712
Location:41 → 326

dNK; Deoxynucleoside kinase
XM_039107340.2 → XP_038963268.1 deoxyguanosine kinase, mitochondrial isoform X14

UniProtKB/TrEMBL

B5DEP0

Conserved Domains (1) summary

cl17190
Location:1 → 178

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_063285802.1 → XP_063141872.1 deoxyguanosine kinase, mitochondrial isoform X10
XM_063285804.1 → XP_063141874.1 deoxyguanosine kinase, mitochondrial isoform X13
XM_063285801.1 → XP_063141871.1 deoxyguanosine kinase, mitochondrial isoform X9
XM_063285803.1 → XP_063141873.1 deoxyguanosine kinase, mitochondrial isoform X11
XM_006236736.5 → XP_006236798.1 deoxyguanosine kinase, mitochondrial isoform X5

UniProtKB/TrEMBL

A6IAM6

Conserved Domains (1) summary

cl17190
Location:41 → 293

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039107341.2 → XP_038963269.1 deoxyguanosine kinase, mitochondrial isoform X12

UniProtKB/TrEMBL

A6IAM9

Conserved Domains (1) summary

cl17190
Location:41 → 148

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_039107338.2 → XP_038963266.1 deoxyguanosine kinase, mitochondrial isoform X8

Conserved Domains (1) summary

cl17190
Location:41 → 147

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...