Rb1cc1 RB1-inducible coiled-coil 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rb1cc1provided by RGD
Official Full Name: RB1-inducible coiled-coil 1provided by RGD
Primary source: RGD:1309346
See related: Ensembl:ENSRNOG00000006833 AllianceGenome:RGD:1309346
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable molecular adaptor activity and protein kinase binding activity. Predicted to be involved in several processes, including autophagy of mitochondrion; macroautophagy; and piecemeal microautophagy of the nucleus. Predicted to act upstream of or within several processes, including liver development; positive regulation of cell size; and regulation of signal transduction. Predicted to be located in several cellular components, including nuclear membrane; phagophore assembly site; and vacuole. Predicted to be part of Atg1/ULK1 kinase complex. Predicted to be active in phagophore assembly site membrane. Predicted to be extrinsic component of membrane. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RB1CC1 (RB1 inducible coiled-coil 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 366.7), Muscle (RPKM 233.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q12

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (17948522..18012434, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (13161648..13225560, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (13033918..13097369, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BF390556 (e-PCR)
- UniSTS:249496

RH127582 (e-PCR)
- UniSTS:210892

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-membrane adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	ISO Inferred from Sequence Orthology more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein lipidation	ISO Inferred from Sequence Orthology more info
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within reticulophagy	ISO Inferred from Sequence Orthology more info
involved_in ribophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Atg1/ULK1 kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Atg1/ULK1 kinase complex	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in phagophore assembly site	ISO Inferred from Sequence Orthology more info
located_in phagophore assembly site	ISO Inferred from Sequence Orthology more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RB1-inducible coiled-coil protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107901.1 → NP_001101371.1 RB1-inducible coiled-coil protein 1

See identical proteins and their annotated locations for NP_001101371.1

Status: PROVISIONAL

Source sequence(s)

CH473984

UniProtKB/TrEMBL

A0A8I6AJ48, A6JFI0, D3ZHK4

Related

ENSRNOP00000060201.1, ENSRNOT00000061884.3

Conserved Domains (4) summary

pfam10377
Location:1456 → 1582

ATG11; Autophagy-related protein 11

pfam13476
Location:1162 → 1269

AAA_23; AAA domain

pfam13949
Location:1020 → 1304

ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

cl00155
Location:3 → 77

UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

17948522..18012434 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237794.5 → XP_006237856.1 RB1-inducible coiled-coil protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AJ48

Conserved Domains (4) summary

pfam10377
Location:1456 → 1579

ATG11; Autophagy-related protein 11

pfam13476
Location:1162 → 1269

AAA_23; AAA domain

pfam13949
Location:1020 → 1304

ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

cl00155
Location:3 → 77

UBQ; Ubiquitin-like proteins
XM_039109749.2 → XP_038965677.1 RB1-inducible coiled-coil protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I6AJ48

Conserved Domains (2) summary

COG0419
Location:631 → 1175

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

pfam10377
Location:1258 → 1384

ATG11; Autophagy-related protein 11
XM_063287519.1 → XP_063143589.1 RB1-inducible coiled-coil protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I6AIK3, A0A8I6AJ48