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    Uba7 ubiquitin-like modifier activating enzyme 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301000, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Uba7provided by RGD
    Official Full Name
    ubiquitin-like modifier activating enzyme 7provided by RGD
    Primary source
    RGD:1308323
    See related
    EnsemblRapid:ENSRNOG00000029195 AllianceGenome:RGD:1308323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ube1l
    Summary
    Predicted to enable ISG15 activating enzyme activity and ubiquitin-protein transferase activity. Predicted to be involved in DNA damage response; ISG15-protein conjugation; and innate immune response. Predicted to act upstream of or within modification-dependent protein catabolic process. Predicted to be active in cytoplasm. Orthologous to human UBA7 (ubiquitin like modifier activating enzyme 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 65.3), Spleen (RPKM 55.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uba7 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117543902..117552709)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108665289..108674097)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116754178..116766765)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene CaM kinase-like vesicle-associated Neighboring gene TRAF-interacting protein Neighboring gene inka box actin regulator 1 Neighboring gene uncharacterized LOC134480233 Neighboring gene cadherin-related family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus. Giannakopoulos NV, et al. J Virol, 2009 Feb. PMID 19073728, Free PMC Article
    2. Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Kim KI, et al. Mol Cell Biol, 2006 Jan. PMID 16382139, Free PMC Article
    3. The basis for selective E1-E2 interactions in the ISG15 conjugation system. Durfee LA, et al. J Biol Chem, 2008 Aug 29. PMID 18583345, Free PMC Article
    4. Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. Takeuchi T, et al. J Biochem, 2005 Dec. PMID 16428300
    5. Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Giannakopoulos NV, et al. Biochem Biophys Res Commun, 2005 Oct 21. PMID 16139798

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ISG15 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ISG15 activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ISG15-protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ISG15-protein conjugation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ISG15-protein conjugation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within modification-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-like modifier-activating enzyme 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393920.1 → NP_001380849.1  ubiquitin-like modifier-activating enzyme 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K735
      Conserved Domains (1) summary
      TIGR01408
      Location:1 → 988
      Ube1; ubiquitin-activating enzyme E1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117543902..117552709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243741.4 → XP_006243803.1  ubiquitin-like modifier-activating enzyme 7 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K735
      Related
      ENSRNOP00000074046.3, ENSRNOT00000084429.3
      Conserved Domains (4) summary
      cd01491
      Location:5 → 386
      Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
      TIGR01408
      Location:1 → 987
      Ube1; ubiquitin-activating enzyme E1
      pfam16191
      Location:254 → 317
      E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
      cl22428
      Location:421 → 944
      E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...

    2. XM_039081230.2 → XP_038937158.1  ubiquitin-like modifier-activating enzyme 7 isoform X2

      Conserved Domains (1) summary
      TIGR01408
      Location:1 → 952
      Ube1; ubiquitin-activating enzyme E1

    3. XM_039081231.2 → XP_038937159.1  ubiquitin-like modifier-activating enzyme 7 isoform X3

      Conserved Domains (1) summary
      TIGR01408
      Location:1 → 951
      Ube1; ubiquitin-activating enzyme E1

    4. XM_039081233.2 → XP_038937161.1  ubiquitin-like modifier-activating enzyme 7 isoform X5

      Conserved Domains (1) summary
      TIGR01408
      Location:1 → 728
      Ube1; ubiquitin-activating enzyme E1

    5. XM_039081232.2 → XP_038937160.1  ubiquitin-like modifier-activating enzyme 7 isoform X4

      Conserved Domains (1) summary
      TIGR01408
      Location:5 → 863
      Ube1; ubiquitin-activating enzyme E1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106856.1: Suppressed sequence

      Description
      NM_001106856.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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