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    Slu7 SLU7 homolog, splicing factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303057, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Slu7provided by RGD
    Official Full Name
    SLU7 homolog, splicing factorprovided by RGD
    Primary source
    RGD:631432
    See related
    EnsemblRapid:ENSRNOG00000003822 AllianceGenome:RGD:631432
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable pre-mRNA 3'-splice site binding activity; second spliceosomal transesterification activity; and zinc ion binding activity. Predicted to be involved in cellular response to heat; intracellular protein transport; and mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear speck. Predicted to be part of catalytic step 2 spliceosome and small nuclear ribonucleoprotein complex. Orthologous to human SLU7 (SLU7 homolog, splicing factor). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Thymus (RPKM 92.3), Spleen (RPKM 89.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slu7 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (28406908..28425253)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (27908325..27923784)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (29029556..29044919)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480673 Neighboring gene microRNA 146a Neighboring gene PTTG1 regulator of sister chromatid separation, securin Neighboring gene C1q and TNF related 2 Neighboring gene uncharacterized LOC108352074

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A day in the life of the spliceosome. Matera AG, et al. Nat Rev Mol Cell Biol, 2014 Feb. PMID 24452469, Free PMC Article
    2. Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing. Shomron N, et al. J Cell Sci, 2005 Mar 15. PMID 15728250
    3. Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus. Shomron N, et al. Mol Biol Cell, 2004 Aug. PMID 15181151, Free PMC Article
    4. Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing. Chua K, et al. Genes Dev, 1999 Apr 1. PMID 10197984, Free PMC Article
    5. Genomic organization and identification of an enhancer element containing binding sites for multiple proteins in rat pituitary tumor-transforming gene. Pei L. J Biol Chem, 1998 Feb 27. PMID 9478977

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables pre-mRNA 3'-splice site binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA 3'-splice site binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pre-mRNA 3'-splice site binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables second spliceosomal transesterification activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables second spliceosomal transesterification activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA splicing, via transesterification reactions ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA splicing, via transesterification reactions ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA 3'-splice site recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-splice site recognition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of small nuclear ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small nuclear ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pre-mRNA-splicing factor SLU7
    Names
    SLU7 splicing factor homolog
    step II splicing factor SLU7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100550.1 → NP_001094020.1  pre-mRNA-splicing factor SLU7

      See identical proteins and their annotated locations for NP_001094020.1

      Status: VALIDATED

      Source sequence(s)
      BC062243, BC158865
      UniProtKB/Swiss-Prot
      Q6P6G1, Q80ZG5
      UniProtKB/TrEMBL
      A0A0G2K1S0, B0BNL0
      Related
      ENSRNOP00000005132.4, ENSRNOT00000005132.7
      Conserved Domains (1) summary
      pfam11708
      Location:161 → 434
      Slu7; Pre-mRNA splicing Prp18-interacting factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      28406908..28425253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268963.1 → XP_063125033.1  pre-mRNA-splicing factor SLU7 isoform X1

      UniProtKB/Swiss-Prot
      Q6P6G1, Q80ZG5
      UniProtKB/TrEMBL
      B0BNL0

    2. XM_008767642.4 → XP_008765864.1  pre-mRNA-splicing factor SLU7 isoform X1

      See identical proteins and their annotated locations for XP_008765864.1

      UniProtKB/Swiss-Prot
      Q6P6G1, Q80ZG5
      UniProtKB/TrEMBL
      A0A0G2K1S0, B0BNL0
      Conserved Domains (1) summary
      pfam11708
      Location:161 → 434
      Slu7; Pre-mRNA splicing Prp18-interacting factor

    3. XM_063268962.1 → XP_063125032.1  pre-mRNA-splicing factor SLU7 isoform X1

      UniProtKB/Swiss-Prot
      Q6P6G1, Q80ZG5
      UniProtKB/TrEMBL
      B0BNL0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZG5.2 GenPept UniProtKB/Swiss-Prot:Q80ZG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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