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    Sorcs1 sortilin-related VPS10 domain containing receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309533, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sorcs1provided by RGD
    Official Full Name
    sortilin-related VPS10 domain containing receptor 1provided by RGD
    Primary source
    RGD:1305910
    See related
    EnsemblRapid:ENSRNOG00000011313 AllianceGenome:RGD:1305910
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in post-Golgi vesicle-mediated transport. Predicted to be active in Golgi apparatus and membrane. Used to study proteinuria. Orthologous to human SORCS1 (sortilin related VPS10 domain containing receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 68.6), Kidney (RPKM 23.3) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sorcs1 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (259022007..259535731, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (249080662..249594520, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (269965824..270473097, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554215 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 4 Neighboring gene uncharacterized LOC134485246 Neighboring gene uncharacterized LOC120097667 Neighboring gene uncharacterized LOC102554335 Neighboring gene uncharacterized LOC134485247 Neighboring gene large ribosomal subunit protein eL29-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 β-cells. Yau B, et al. Sci Rep, 2019 Dec 19. PMID 31857633, Free PMC Article
    2. SORCS1 contributes to the development of renal disease in rats and humans. Lazar J, et al. Physiol Genomics, 2013 Aug 15. PMID 23780848, Free PMC Article
    3. SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function. Ribeiro LF, et al. PLoS Biol, 2019 Oct. PMID 31658245, Free PMC Article
    4. Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells. Hermey G, et al. J Biol Chem, 2003 Feb 28. PMID 12482870
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 beta-cells.
      Title: Type 2 diabetes-associated single nucleotide polymorphism in Sorcs1 gene results in alternative processing of the Sorcs1 protein in INS1 β-cells.
    2. SorCS1-mediated sorting in dendritic endosomes controls Nrxn axonal surface polarization required for proper synapse development and function.
      Title: SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function.
    3. The experimental data from the rat combined with association results from different ethnic groups indicates a role for SORCS1 in maintaining proper renal function.
      Title: SORCS1 contributes to the development of renal disease in rats and humans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in post-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    VPS10 domain-containing receptor SorCS1
    Names
    VPS10 domain receptor protein SORCS 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191563.1 → NP_001178492.1  VPS10 domain-containing receptor SorCS1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1LUZ4
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      259022007..259535731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231521.5 → XP_006231583.1  VPS10 domain-containing receptor SorCS1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLQ5
      Related
      ENSRNOP00000078816.1, ENSRNOT00000108738.2
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

    2. XM_006231519.5 → XP_006231581.1  VPS10 domain-containing receptor SorCS1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEA1
      Related
      ENSRNOP00000091270.2, ENSRNOT00000098704.2
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

    3. XM_006231520.5 → XP_006231582.1  VPS10 domain-containing receptor SorCS1 isoform X2

      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

    4. XM_006231525.4 → XP_006231587.1  VPS10 domain-containing receptor SorCS1 isoform X7

      Related
      ENSRNOP00000090827.2, ENSRNOT00000099121.2
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

    5. XM_039080712.2 → XP_038936640.1  VPS10 domain-containing receptor SorCS1 isoform X6

      Conserved Domains (2) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain

    6. XM_006231523.5 → XP_006231585.1  VPS10 domain-containing receptor SorCS1 isoform X5

      Related
      ENSRNOP00000015979.4, ENSRNOT00000015979.6
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

    7. XM_063265314.1 → XP_063121384.1  VPS10 domain-containing receptor SorCS1 isoform X11

    8. XM_039080717.2 → XP_038936645.1  VPS10 domain-containing receptor SorCS1 isoform X8

      UniProtKB/TrEMBL
      A6JHS6
      Conserved Domains (2) summary
      smart00602
      Location:20 → 617
      VPS10; VPS10 domain
      pfam00801
      Location:631 → 704
      PKD; PKD domain

    9. XM_039080727.1 → XP_038936655.1  VPS10 domain-containing receptor SorCS1 isoform X10

      Conserved Domains (2) summary
      smart00602
      Location:1 → 316
      VPS10; VPS10 domain
      pfam00801
      Location:330 → 403
      PKD; PKD domain

    10. XM_039080722.2 → XP_038936650.1  VPS10 domain-containing receptor SorCS1 isoform X9

      Conserved Domains (2) summary
      smart00602
      Location:26 → 348
      VPS10; VPS10 domain
      pfam00801
      Location:362 → 435
      PKD; PKD domain

    11. XM_006231522.5 → XP_006231584.1  VPS10 domain-containing receptor SorCS1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AF53
      Conserved Domains (3) summary
      smart00602
      Location:196 → 793
      VPS10; VPS10 domain
      pfam00801
      Location:807 → 880
      PKD; PKD domain
      pfam15901
      Location:638 → 793
      Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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