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    Kctd12 potassium channel tetramerization domain containing 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364458, updated on 28-Oct-2024

    Summary

    Symbol
    Kctd12provided by RGD
    Full Name
    potassium channel tetramerization domain containing 12provided by RGD
    Primary source
    RGD:1309421
    See related
    EnsemblRapid:ENSRNOG00000066973 AllianceGenome:RGD:1309421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential; and identical protein binding activity. Predicted to be involved in protein homooligomerization; regulation of postsynaptic membrane potential; and regulation of presynaptic membrane potential. Predicted to act upstream of or within regulation of G protein-coupled receptor signaling pathway. Is active in postsynaptic membrane and presynaptic membrane. Orthologous to human KCTD12 (potassium channel tetramerization domain containing 12). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See Kctd12 in Genome Data Viewer
    Location:
    15q21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (86214786..86220725, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (79800078..79806017, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (87384632..87390627, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546300 Neighboring gene uncharacterized LOC102546379 Neighboring gene uncharacterized LOC134482003 Neighboring gene uncharacterized LOC120097063 Neighboring gene aconitate decarboxylase 1

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    BTB/POZ domain-containing protein KCTD12
    Names
    potassium channel tetramerisation domain containing 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399515.1NP_001386444.1  BTB/POZ domain-containing protein KCTD12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HU83
      Related
      ENSRNOP00000077409.2, ENSRNOT00000110749.2
      Conserved Domains (2) summary
      cd18397
      Location:32131
      BTB_POZ_KCTD12_Pfetin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12)
      cd22217
      Location:208327
      H1_KCTD12; H1 domain found in potassium channel tetramerization domain-containing protein 12

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      86214786..86220725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)