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    Elmod2 ELMO domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688581, updated on 10-Jul-2024

    Summary

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    Symbol
    Elmod2provided by RGD
    Full Name
    ELMO domain containing 2provided by RGD
    Primary source
    RGD:1587598
    See related
    EnsemblRapid:ENSRNOG00000028176 AllianceGenome:RGD:1587598
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307344
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of defense response to virus. Orthologous to human ELMOD2 (ELMO domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 88.9), Kidney (RPKM 82.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elmod2 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41690713..41710194)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24786166..24805626)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (24467964..24487445, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene calmegin Neighboring gene MGAT4 family, member D Neighboring gene uncoupling protein 1 Neighboring gene TBC1 domain family member 9 Neighboring gene uncharacterized LOC134483334

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs. Bowzard JB, et al. J Biol Chem, 2007 Jun 15. PMID 17452337
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ELMO domain-containing protein 2
    Names
    ELMO domain-containing protein 2-like
    ELMO/CED-12 domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109506.1 → NP_001102976.1  ELMO domain-containing protein 2

      See identical proteins and their annotated locations for NP_001102976.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IYF4, D3ZNV6, M0RC60
      Related
      ENSRNOP00000037996.2, ENSRNOT00000031614.5
      Conserved Domains (1) summary
      pfam04727
      Location:110 → 268
      ELMO_CED12; ELMO/CED-12 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      41690713..41710194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255303.5 → XP_006255365.1  ELMO domain-containing protein 2 isoform X2

      Conserved Domains (1) summary
      pfam04727
      Location:112 → 202
      ELMO_CED12; ELMO/CED-12 family

    2. XM_006255302.5 → XP_006255364.1  ELMO domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006255364.1

      UniProtKB/TrEMBL
      A6IYF4, D3ZNV6, M0RC60
      Conserved Domains (1) summary
      pfam04727
      Location:110 → 268
      ELMO_CED12; ELMO/CED-12 family

    3. XM_063278289.1 → XP_063134359.1  ELMO domain-containing protein 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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