Eps8 EGFR pathway substrate 8, signaling adaptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eps8provided by RGD
Official Full Name: EGFR pathway substrate 8, signaling adaptorprovided by RGD
Primary source: RGD:1310590
See related: Ensembl:ENSRNOG00000007047 AllianceGenome:RGD:1310590
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; actin filament organization; and barbed-end actin filament capping. Predicted to act upstream of or within several processes, including actin cytoskeleton reorganization; behavioral response to ethanol; and cellular response to leukemia inhibitory factor. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (epidermal growth factor receptor pathway substrate 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 273.4), Brain (RPKM 64.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (172119497..172291670, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (170388378..170486873, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (171475155..171645620, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings demonstrate a novel role for Wnt-Dvl1 signalling through Eps8 in the regulation of axonal remodeling.
Title: Wnt Signalling Promotes Actin Dynamics during Axon Remodelling through the Actin-Binding Protein Eps8.
Data suggest that fascin 1 is involved in localization of actin-bundling proteins Eps8 and paladin during spermatogenesis; thus, fascin 1 regulates cytoskeletal filaments in Sertoli cells and in spermatid polarity.
Title: Fascin 1 is an actin filament-bundling protein that regulates ectoplasmic specialization dynamics in the rat testis.
Eps8 regulates the balance between excitatory synapses on spines and on the dendritic shaft.
Title: Activity-dependent spine morphogenesis: a role for the actin-capping protein Eps8.
knockdown of Eps8 by RNAi led to F-actin disorganization and the mislocalization of the tight junction proteins occludin and ZO-1, suggesting the function of Eps8 in maintaining blood-testis barrier integrity
Title: Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier integrity in the seminiferous epithelium.
expression of LanCL1 mutants defective in Eps8 interaction inhibits nerve growth factor (NGF)-induced neurite outgrowth
Title: Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141106 (e-PCR)
- UniSTS:223102

RH139755 (e-PCR)
- UniSTS:221839

BF406009 (e-PCR)
- UniSTS:248260

D4Rat277 (e-PCR), detects polymorphism
- UniSTS:227819

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rac protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin crosslink formation	IEA Inferred from Electronic Annotation more info
involved_in actin crosslink formation	ISO Inferred from Sequence Orthology more info
involved_in actin crosslink formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin polymerization-dependent cell motility	IEA Inferred from Electronic Annotation more info
involved_in actin polymerization-dependent cell motility	ISO Inferred from Sequence Orthology more info
involved_in actin polymerization-dependent cell motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in adult locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in barbed-end actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in barbed-end actin filament capping	ISS Inferred from Sequence or Structural Similarity more info
involved_in behavioral response to ethanol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavioral response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell migration	IEA Inferred from Electronic Annotation more info
involved_in dendritic cell migration	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in exit from mitosis	IEA Inferred from Electronic Annotation more info
involved_in exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in exit from mitosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ruffle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin filament length	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament length	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IEA Inferred from Electronic Annotation more info
part_of NMDA selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in ruffle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in stereocilium	ISO Inferred from Sequence Orthology more info
located_in stereocilium	ISS Inferred from Sequence or Structural Similarity more info
located_in stereocilium bundle	ISO Inferred from Sequence Orthology more info
located_in stereocilium tip	IEA Inferred from Electronic Annotation more info
located_in stereocilium tip	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: epidermal growth factor receptor kinase substrate 8

Names: epidermal growth factor receptor pathway substrate 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001376935.1 → NP_001363864.1 epidermal growth factor receptor kinase substrate 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

F1M3L7

UniProtKB/TrEMBL

A0A8L2Q453

Related

ENSRNOP00000009328.7, ENSRNOT00000009328.8

Conserved Domains (3) summary

cd09540
Location:720 → 784

SAM_EPS8-like; SAM domain of EPS8-like subfamily

cd11764
Location:535 → 588

SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

cd01210
Location:64 → 191

PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

172119497..172291670 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286164.1 → XP_063142234.1 epidermal growth factor receptor kinase substrate 8 isoform X1

UniProtKB/Swiss-Prot

F1M3L7
XM_063286162.1 → XP_063142232.1 epidermal growth factor receptor kinase substrate 8 isoform X2
XM_063286158.1 → XP_063142228.1 epidermal growth factor receptor kinase substrate 8 isoform X1

UniProtKB/Swiss-Prot

F1M3L7
XM_063286160.1 → XP_063142230.1 epidermal growth factor receptor kinase substrate 8 isoform X1

UniProtKB/Swiss-Prot

F1M3L7
XM_063286163.1 → XP_063142233.1 epidermal growth factor receptor kinase substrate 8 isoform X2
XM_063286159.1 → XP_063142229.1 epidermal growth factor receptor kinase substrate 8 isoform X1

UniProtKB/Swiss-Prot

F1M3L7
XM_063286161.1 → XP_063142231.1 epidermal growth factor receptor kinase substrate 8 isoform X1

UniProtKB/Swiss-Prot

F1M3L7