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    Gstp3 glutathione S-transferase pi 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293656, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gstp3provided by RGD
    Official Full Name
    glutathione S-transferase pi 3provided by RGD
    Primary source
    RGD:1307603
    See related
    EnsemblRapid:ENSRNOG00000018287 AllianceGenome:RGD:1307603
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307603
    Summary
    Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 1404.7) See more
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    Genomic context

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    See Gstp3 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210785151..210787705, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201355682..201358216, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219309593..219312240, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483955 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1 Neighboring gene glutathione S-transferase pi 1 Neighboring gene calcium binding protein 2 Neighboring gene cyclin-dependent kinase 2 associated protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Glutathione S-transferase P-like; glutathione S-transferase P-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134508.2 → NP_001127980.1  Glutathione S-transferase P-like isoform 2

      See identical proteins and their annotated locations for NP_001127980.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HYR9, A6HYS0, D4A8S2
      Related
      ENSRNOP00000059097.1, ENSRNOT00000066691.3
      Conserved Domains (3) summary
      PTZ00057
      Location:6 → 158
      PTZ00057; glutathione s-transferase; Provisional
      cd03076
      Location:3 → 74
      GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:84 → 166
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. NM_001398780.1 → NP_001385709.1  Glutathione S-transferase P-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K4Q5
      Related
      ENSRNOP00000073133.2, ENSRNOT00000085439.3
      Conserved Domains (2) summary
      cd03076
      Location:3 → 74
      GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:84 → 202
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210785151..210787705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230737.3 → XP_006230799.1  glutathione S-transferase P-like isoform X1

      UniProtKB/TrEMBL
      A6HYS0
      Conserved Domains (3) summary
      COG0625
      Location:2 → 189
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cl00388
      Location:1 → 57
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:67 → 185
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. XM_039108270.2 → XP_038964198.1  glutathione S-transferase P-like isoform X2

      Conserved Domains (1) summary
      cl02776
      Location:1 → 111
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
    Nucleotide Protein Strain
    Heading Accession and Version

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