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    Myrip myosin VIIA and Rab interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360034, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Myripprovided by RGD
    Official Full Name
    myosin VIIA and Rab interacting proteinprovided by RGD
    Primary source
    RGD:727731
    See related
    EnsemblRapid:ENSRNOG00000018797 AllianceGenome:RGD:727731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slac2c
    Summary
    Enables protein kinase A binding activity. Involved in positive regulation of insulin secretion. Located in apical plasma membrane; dense core granule; and perinuclear region of cytoplasm. Orthologous to human MYRIP (myosin VIIA and Rab interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 68.6), Lung (RPKM 45.8) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myrip in Genome Data Viewer
    Location:
    8q32
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128895371..129062420)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (120017749..120184821)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128972307..129139257)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosome recycling factor, pseudogene 2 Neighboring gene uncharacterized LOC102549350 Neighboring gene uncharacterized LOC108351802 Neighboring gene uncharacterized LOC120094297 Neighboring gene transfer RNA proline (anticodon AGG) 29 Neighboring gene eukaryotic translation initiation factor 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. Imai A, et al. J Cell Sci, 2004 Apr 15. PMID 15039459
    2. MyRIP anchors protein kinase A to the exocyst complex. Goehring AS, et al. J Biol Chem, 2007 Nov 9. PMID 17827149, Free PMC Article
    3. MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. El-Amraoui A, et al. EMBO Rep, 2002 May. PMID 11964381, Free PMC Article
    4. Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. Fukuda M, et al. J Biol Chem, 2002 Nov 8. PMID 12221080
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the Rab27B-Slac2-c complex is an important constituent of secretory granule exocytosis in parotid acinar cells
      Title: The small GTPase Rab27B regulates amylase release from rat parotid acinar cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase A binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dense core granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exocyst ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rab effector MyRIP
    Names
    exophilin-8
    myosin-VIIa- and Rab-interacting protein
    slaC2-c
    slp homolog lacking C2 domains c
    synaptotagmin-like protein lacking C2 domains C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182844.3 → NP_878264.2  rab effector MyRIP

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D3ZTL2
      Related
      ENSRNOP00000025460.6, ENSRNOT00000025460.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      128895371..129062420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081681.2 → XP_038937609.1  rab effector MyRIP isoform X1

      UniProtKB/Swiss-Prot
      Q7TNY7
      Related
      ENSRNOP00000104715.1, ENSRNOT00000164781.1
      Conserved Domains (2) summary
      pfam02318
      Location:8 → 151
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:178 → 882
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

    2. XM_039081687.2 → XP_038937615.1  rab effector MyRIP isoform X4

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8 → 151
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:178 → 817
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

    3. XM_039081688.2 → XP_038937616.1  rab effector MyRIP isoform X5

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8 → 125
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:152 → 791
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

    4. XM_039081682.2 → XP_038937610.1  rab effector MyRIP isoform X1

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8 → 151
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:178 → 882
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

    5. XM_039081685.2 → XP_038937613.1  rab effector MyRIP isoform X1

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8 → 151
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:178 → 882
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

    6. XM_063265675.1 → XP_063121745.1  rab effector MyRIP isoform X2

      UniProtKB/TrEMBL
      D3ZTL2

    7. XM_039081683.2 → XP_038937611.1  rab effector MyRIP isoform X1

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8 → 151
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:178 → 882
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

    8. XM_039081684.2 → XP_038937612.1  rab effector MyRIP isoform X1

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam02318
      Location:8 → 151
      FYVE_2; FYVE-type zinc finger
      pfam04698
      Location:178 → 882
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

    9. XM_063265676.1 → XP_063121746.1  rab effector MyRIP isoform X2

      UniProtKB/TrEMBL
      D3ZTL2

    10. XM_039081686.2 → XP_038937614.1  rab effector MyRIP isoform X3

      UniProtKB/Swiss-Prot
      Q7TNY7
      Conserved Domains (2) summary
      pfam04698
      Location:140 → 844
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
      cl22851
      Location:1 → 113
      PHD_SF; PHD finger superfamily

    11. XM_008766687.4 → XP_008764909.1  rab effector MyRIP isoform X6

      See identical proteins and their annotated locations for XP_008764909.1

      Conserved Domains (1) summary
      pfam04698
      Location:1 → 670
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus

    12. XM_039081689.2 → XP_038937617.1  rab effector MyRIP isoform X6

      Conserved Domains (1) summary
      pfam04698
      Location:1 → 670
      Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNY7.1 GenPept UniProtKB/Swiss-Prot:Q7TNY7

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