Edem1 ER degradation enhancing alpha-mannosidase like protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Edem1provided by RGD
Official Full Name: ER degradation enhancing alpha-mannosidase like protein 1provided by RGD
Primary source: RGD:1563633
See related: EnsemblRapid:ENSRNOG00000055365 AllianceGenome:RGD:1563633
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563633
Summary: Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity and misfolded protein binding activity. Predicted to be involved in several processes, including positive regulation of retrograde protein transport, ER to cytosol; proteolysis involved in protein catabolic process; and trimming of terminal mannose on C branch. Predicted to act upstream of or within ERAD pathway. Predicted to be located in aggresome; endoplasmic reticulum membrane; and endoplasmic reticulum quality control compartment. Predicted to be active in endoplasmic reticulum. Orthologous to human EDEM1 (ER degradation enhancing alpha-mannosidase like protein 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Liver (RPKM 531.1), Lung (RPKM 308.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q41

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (143350989..143385693)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (141797631..141829717)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (140886644..140918654)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the endoplasmic reticulum quality control vesicular transport pathway using EDEM1 does not involve the COPII exit sites
Title: EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132662 (e-PCR)
- UniSTS:215945

RH129325 (e-PCR)
- UniSTS:212632

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables alpha-mannosidase activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
NOT enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	ISO Inferred from Sequence Orthology more info
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	ISO Inferred from Sequence Orthology more info
enables misfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mannoprotein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mannoprotein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mannose trimming involved in glycoprotein ERAD pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to ER	ISO Inferred from Sequence Orthology more info
involved_in trimming of terminal mannose on C branch	IEA Inferred from Electronic Annotation more info
involved_in trimming of terminal mannose on C branch	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent glycoprotein ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in aggresome	IEA Inferred from Electronic Annotation more info
located_in aggresome	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum quality control compartment	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ER degradation-enhancing alpha-mannosidase-like protein 1

Names: ER degradation enhancer, mannosidase alpha-like 1; ER degradation-enhancing alpha-mannosidase-like 1

NP_001292208.1

EC 3.2.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305279.1 → NP_001292208.1 ER degradation-enhancing alpha-mannosidase-like protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

D3ZJE0

Related

ENSRNOP00000069931.1, ENSRNOT00000088273.3

Conserved Domains (1) summary

pfam01532
Location:130 → 575

Glyco_hydro_47; Glycosyl hydrolase family 47