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    Slc25a16 solute carrier family 25 member 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361836, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc25a16provided by RGD
    Official Full Name
    solute carrier family 25 member 16provided by RGD
    Primary source
    RGD:1311311
    See related
    EnsemblRapid:ENSRNOG00000000387 EnsemblRapid:ENSRNOG00000071263 AllianceGenome:RGD:1311311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; catalytic activity, acting on DNA; and coenzyme A transmembrane transporter activity. Predicted to be involved in DNA metabolic process; DNA replication checkpoint signaling; and mitochondrial coenzyme A transmembrane transport. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human SLC25A16 (solute carrier family 25 member 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 96.2), Kidney (RPKM 96.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a16 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (25659847..25717080, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (25691474..25717558, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (27283383..27308069, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene RUN and FYVE domain containing 2 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene DNA replication helicase/nuclease 2 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene U6 spliceosomal RNA Neighboring gene elongin C, pseduogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sequence and chromosomal assignment of a novel cDNA identified by immunoscreening of a thyroid expression library: similarity to a family of mitochondrial solute carrier proteins. Zarrilli R, et al. Mol Endocrinol, 1989 Sep. PMID 2575220
    2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-3' DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 5'-flap endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-flap endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables coenzyme A transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables single-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA double-strand break processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA replication checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA replication, Okazaki fragment processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication, Okazaki fragment processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in base-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial coenzyme A transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 25 member 16
    Names
    GDC
    graves disease carrier protein
    mitochondrial solute carrier protein homolog
    solute carrier family 25 (mitochondrial carrier), member 16
    solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100860.4 → NP_001094330.1  solute carrier family 25 member 16 isoform 1

      See identical proteins and their annotated locations for NP_001094330.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      P16261
      UniProtKB/TrEMBL
      A0A9K3Y7D2, B2GV20, F1MA22
      Related
      ENSRNOP00000052899.5, ENSRNOT00000056047.5
      Conserved Domains (1) summary
      PTZ00169
      Location:36 → 330
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

    2. NM_001429292.1 → NP_001416221.1  solute carrier family 25 member 16 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      25659847..25717080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279286.1 → XP_063135356.1  solute carrier family 25 member 16 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZI9
      Related
      ENSRNOP00000083522.1, ENSRNOT00000103093.3

    2. XM_063279289.1 → XP_063135359.1  solute carrier family 25 member 16 isoform X4

    3. XM_063279288.1 → XP_063135358.1  solute carrier family 25 member 16 isoform X3

    4. XM_063279287.1 → XP_063135357.1  solute carrier family 25 member 16 isoform X2

    5. XM_039098864.2 → XP_038954792.1  solute carrier family 25 member 16 isoform X5

      UniProtKB/Swiss-Prot
      P16261
      Conserved Domains (1) summary
      PTZ00169
      Location:36 → 272
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16261.1 GenPept UniProtKB/Swiss-Prot:P16261

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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