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    Tex15 testis expressed 15, meiosis and synapsis associated [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290803, updated on 28-Oct-2024

    Summary

    Official Symbol
    Tex15provided by RGD
    Official Full Name
    testis expressed 15, meiosis and synapsis associatedprovided by RGD
    Primary source
    RGD:1311266
    See related
    EnsemblRapid:ENSRNOG00000007748 AllianceGenome:RGD:1311266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in meiotic nuclear division; piRNA-mediated retrotransposon silencing by heterochromatin formation; and regulation of double-strand break repair via homologous recombination. Predicted to act upstream of or within with a positive effect on DNA methylation-dependent heterochromatin formation. Predicted to act upstream of or within several processes, including homeostasis of number of cells within a tissue; homologous chromosome pairing at meiosis; and male genitalia development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 25. Orthologous to human TEX15 (testis expressed 15, meiosis and synapsis associated). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Testes (RPKM 110.5), Adrenal (RPKM 28.3) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tex15 in Genome Data Viewer
    Location:
    16q12.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (65302049..65362065, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (58598991..58659005, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (62313284..62373288, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 catalytic subunit beta Neighboring gene ribosomal protein S25, pseudogene 6 Neighboring gene uncharacterized LOC134482400 Neighboring gene small ribosomal subunit protein uS8-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect DNA methylation-dependent heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within fertilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within male genitalia development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male meiotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in piRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in piRNA-mediated retrotransposon silencing by heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retrotransposon silencing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synaptonemal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within synaptonemal complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    testis-expressed protein 15
    Names
    testis expressed gene 15
    testis-expressed sequence 15 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106087.2NP_001099557.2  testis-expressed protein 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6A4Z7
      Conserved Domains (3) summary
      pfam12509
      Location:99246
      DUF3715; Protein of unknown function (DUF3715)
      pfam15326
      Location:18512064
      TEX15; Testis expressed sequence 15
      NF033845
      Location:25522771
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      65302049..65362065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094393.1XP_038950321.1  testis-expressed protein 15 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A4Z7
      Conserved Domains (3) summary
      pfam12509
      Location:1147
      DUF3715; Protein of unknown function (DUF3715)
      pfam15326
      Location:17521965
      TEX15; Testis expressed sequence 15
      NF033845
      Location:24532672
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    2. XM_008771296.3XP_008769518.1  testis-expressed protein 15 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4Z7, D3ZYB8
      Related
      ENSRNOP00000032440.5, ENSRNOT00000034325.7
      Conserved Domains (3) summary
      pfam05466
      Location:25622696
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam12509
      Location:96251
      DUF3715; Protein of unknown function (DUF3715)
      pfam15326
      Location:18552069
      TEX15; Testis expressed sequence 15
    3. XM_008771298.4XP_008769520.1  testis-expressed protein 15 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A4Z7
      Conserved Domains (3) summary
      pfam12509
      Location:99246
      DUF3715; Protein of unknown function (DUF3715)
      pfam15326
      Location:18512064
      TEX15; Testis expressed sequence 15
      NF033845
      Location:25522771
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    4. XM_063275238.1XP_063131308.1  testis-expressed protein 15 isoform X4