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    Sufu SUFU negative regulator of hedgehog signaling [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361769, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sufuprovided by RGD
    Official Full Name
    SUFU negative regulator of hedgehog signalingprovided by RGD
    Primary source
    RGD:1559462
    See related
    EnsemblRapid:ENSRNOG00000019807 AllianceGenome:RGD:1559462
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable beta-catenin binding activity and protein kinase binding activity. Involved in positive regulation of cellular response to drug and spermatid development. Predicted to be located in cilium and nucleoplasm. Predicted to be part of GLI-SUFU complex. Predicted to be active in cytoplasm and nucleus. Used to study medulloblastoma. Biomarker of brain glioblastoma multiforme and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome 2. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 39.7), Kidney (RPKM 27.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sufu in Genome Data Viewer
    Location:
    1q54
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (255199108..255296983)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (245257725..245355576)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (266143766..266241742)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 13A Neighboring gene actin related protein 1A Neighboring gene uncharacterized LOC134484078 Neighboring gene uncharacterized LOC134484077 Neighboring gene tripartite motif-containing 8 Neighboring gene ADP ribosylation factor like GTPase 3 Neighboring gene transfer RNA histidin (anticodon AUG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Oroxylin A increases the sensitivity of temozolomide on glioma cells by hypoxia-inducible factor 1α/hedgehog pathway under hypoxia. Wei M, et al. J Cell Physiol, 2019 Aug. PMID 30790292
    2. Impact of surgeon laparoscopic training and case volume of laparoscopic surgery on conversion during elective laparoscopic colorectal surgery. Massarotti H, et al. Colorectal Dis, 2017 Jan. PMID 27234928
    3. MicroRNA-874 targeting SUFU involves in osteoblast proliferation and differentiation in osteoporosis rats through the Hedgehog signaling pathway. Lin JC, et al. Biochem Biophys Res Commun, 2018 Nov 17. PMID 30342851
    4. Suppressor of fused negatively regulates beta-catenin signaling. Meng X, et al. J Biol Chem, 2001 Oct 26. PMID 11477086
    5. SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation. Ding X, et al. J Exp Clin Cancer Res, 2019 Sep 13. PMID 31519191, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. through targeted inhibition of SUFU and activation of Hedgehog signaling pathway, miR-874 could promote the proliferation and differentiation of osteoblasts in osteoporosis rats.
      Title: MicroRNA-874 targeting SUFU involves in osteoblast proliferation and differentiation in osteoporosis rats through the Hedgehog signaling pathway.
    2. Glis3 interacts with Suppressor of Fused (SUFU)
      Title: Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aorta development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within coronary vasculature development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cytoplasmic sequestering of transcription factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart looping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cellular response to drug IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skin development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_negative_effect smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway involved in ventral spinal cord interneuron specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within spinal cord dorsal/ventral patterning ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of GLI-SUFU complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of fused homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024899.1 → NP_001020070.1  suppressor of fused homolog

      See identical proteins and their annotated locations for NP_001020070.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097447
      UniProtKB/TrEMBL
      A0A8I6A606, Q4V8C6
      Related
      ENSRNOP00000026987.5, ENSRNOT00000026987.7
      Conserved Domains (2) summary
      pfam05076
      Location:68 → 240
      SUFU; Suppressor of fused protein (SUFU)
      pfam12470
      Location:254 → 474
      SUFU_C; Suppressor of Fused Gli/Ci N terminal binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      255199108..255296983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231546.5 → XP_006231608.1  suppressor of fused homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6A606
      Related
      ENSRNOP00000087532.2, ENSRNOT00000095114.2
      Conserved Domains (2) summary
      pfam05076
      Location:68 → 240
      SUFU; Suppressor of fused protein (SUFU)
      pfam12470
      Location:253 → 473
      SUFU_C; Suppressor of Fused Gli/Ci N terminal binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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