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    Trps1 transcriptional repressor GATA binding 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299897, updated on 28-Oct-2024

    Summary

    Official Symbol
    Trps1provided by RGD
    Official Full Name
    transcriptional repressor GATA binding 1provided by RGD
    Primary source
    RGD:1311883
    See related
    EnsemblRapid:ENSRNOG00000024998 AllianceGenome:RGD:1311883
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including hair follicle development; negative regulation of transcription by RNA polymerase II; and regulation of chondrocyte differentiation. Predicted to act upstream of or within several processes, including cell surface receptor protein serine/threonine kinase signaling pathway; chondrocyte differentiation; and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in osteochondrodysplasia; trichorhinophalangeal syndrome type I; and trichorhinophalangeal syndrome type III. Orthologous to human TRPS1 (transcriptional repressor GATA binding 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Kidney (RPKM 158.2), Thymus (RPKM 106.5) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Trps1 in Genome Data Viewer
    Location:
    7q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (83806121..84032609, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (81916668..82142733, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (90085895..90320430, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479727 Neighboring gene uncharacterized LOC134479603 Neighboring gene uncharacterized LOC120093649 Neighboring gene uncharacterized LOC102548590 Neighboring gene uncharacterized LOC102548754

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger transcription factor Trps1
    Names
    trichorhinophalangeal syndrome I homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134837.1NP_001128309.1  zinc finger transcription factor Trps1

      See identical proteins and their annotated locations for NP_001128309.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A0A8I5Y133, A6HRD1
      Related
      ENSRNOP00000096700.1, ENSRNOT00000110775.2
      Conserved Domains (2) summary
      smart00401
      Location:891934
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:895951
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      83806121..84032609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078765.2XP_038934693.1  zinc finger transcription factor Trps1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y133, D3ZEM6
      Related
      ENSRNOP00000039913.3, ENSRNOT00000050774.4
    2. XM_039078762.2XP_038934690.1  zinc finger transcription factor Trps1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y133
      Related
      ENSRNOP00000083606.2, ENSRNOT00000106247.2
      Conserved Domains (1) summary
      cd00202
      Location:910966
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    3. XM_063263244.1XP_063119314.1  zinc finger transcription factor Trps1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZWX6
      Related
      ENSRNOP00000110301.1, ENSRNOT00000157182.1
    4. XM_039078768.2XP_038934696.1  zinc finger transcription factor Trps1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y133
      Related
      ENSRNOP00000077022.1, ENSRNOT00000094294.2
    5. XM_039078760.2XP_038934688.1  zinc finger transcription factor Trps1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y133
      Conserved Domains (1) summary
      cd00202
      Location:933989
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
    6. XM_039078761.2XP_038934689.1  zinc finger transcription factor Trps1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y133
      Related
      ENSRNOP00000110847.1, ENSRNOT00000146817.1
    7. XM_039078767.2XP_038934695.1  zinc finger transcription factor Trps1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y133, D3ZEM6
    8. XM_039078764.2XP_038934692.1  zinc finger transcription factor Trps1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y133, D3ZEM6
      Conserved Domains (1) summary
      cd00202
      Location:906962
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C