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    Immp2l inner mitochondrial membrane peptidase subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100359529, updated on 2-Nov-2024

    Summary

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    Symbol
    Immp2lprovided by RGD
    Full Name
    inner mitochondrial membrane peptidase subunit 2provided by RGD
    Primary source
    RGD:2323665
    See related
    EnsemblRapid:ENSRNOG00000067070 AllianceGenome:RGD:2323665
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in signal peptide processing. Predicted to act upstream of or within several processes, including cerebellum vasculature development; ovulation; and protein processing involved in protein targeting to mitochondrion. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial inner membrane peptidase complex. Orthologous to human IMMP2L (inner mitochondrial membrane peptidase subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 64.1), Heart (RPKM 57.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Immp2l in Genome Data Viewer
    Location:
    6q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (63797189..64696906)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (58070035..58970165)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (60958351..61859457)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093202 Neighboring gene zinc finger protein 277 Neighboring gene dedicator of cytokinesis 4 Neighboring gene uncharacterized LOC102552766 Neighboring gene uncharacterized LOC120093204 Neighboring gene H3.3 histone like 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120093203 Neighboring gene leucine rich repeat neuronal 3 Neighboring gene uncharacterized LOC134479121 Neighboring gene uncharacterized LOC120103525 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deficiency in the inner mitochondrial membrane peptidase 2-like (Immp21) gene increases ischemic brain damage and impairs mitochondrial function. Ma Y, et al. Neurobiol Dis, 2011 Dec. PMID 21824519, Free PMC Article
    2. A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice. Lu B, et al. Biol Reprod, 2008 Apr. PMID 18094351
    3. Processing of mitochondrial presequences. Mossmann D, et al. Biochim Biophys Acta, 2012 Sep-Oct. PMID 22172993
    4. Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. Burri L, et al. Mol Biol Cell, 2005 Jun. PMID 15814844, Free PMC Article
    5. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within blood circulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebellum vasculature development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitochondrial respiratory chain complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ovulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein processing involved in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within respiratory electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within superoxide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial inner membrane peptidase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial inner membrane protease subunit 2
    Names
    IMP2 inner mitochondrial membrane peptidase-like
    rCG61688-like
    NP_001385633.1
    XP_038934060.1
    XP_038934061.1
    XP_038934062.1
    XP_038934063.1
    XP_038934065.1
    XP_063117436.1
    XP_063117437.1
    XP_063117438.1
    XP_063117439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398704.1 → NP_001385633.1  mitochondrial inner membrane protease subunit 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A7I6, A6HBE0
      Conserved Domains (1) summary
      cd06530
      Location:36 → 146
      S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      63797189..64696906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078133.2 → XP_038934061.1  mitochondrial inner membrane protease subunit 2 isoform X1

      Related
      ENSRNOP00000088187.2, ENSRNOT00000098533.2
      Conserved Domains (1) summary
      cd06530
      Location:36 → 99
      S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

    2. XM_063261368.1 → XP_063117438.1  mitochondrial inner membrane protease subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7I6, A6HBE0

    3. XM_039078135.2 → XP_038934063.1  mitochondrial inner membrane protease subunit 2 isoform X1

      Conserved Domains (1) summary
      cd06530
      Location:36 → 99
      S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

    4. XM_039078134.2 → XP_038934062.1  mitochondrial inner membrane protease subunit 2 isoform X1

      Conserved Domains (1) summary
      cd06530
      Location:36 → 99
      S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

    5. XM_039078132.2 → XP_038934060.1  mitochondrial inner membrane protease subunit 2 isoform X1

      Conserved Domains (1) summary
      cd06530
      Location:36 → 99
      S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

    6. XM_063261369.1 → XP_063117439.1  mitochondrial inner membrane protease subunit 2 isoform X3

    7. XM_039078137.2 → XP_038934065.1  mitochondrial inner membrane protease subunit 2 isoform X1

      Conserved Domains (1) summary
      cd06530
      Location:36 → 99
      S26_SPase_I; The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are ...

    8. XM_063261366.1 → XP_063117436.1  mitochondrial inner membrane protease subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7I6, A6HBE0
      Related
      ENSRNOP00000102398.1, ENSRNOT00000171385.1

    9. XM_063261367.1 → XP_063117437.1  mitochondrial inner membrane protease subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7I6, A6HBE0
      Related
      ENSRNOP00000104080.1, ENSRNOT00000139681.1
    Nucleotide Protein Strain
    Heading Accession and Version

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