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    Hook2 hook microtubule-tethering protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304669, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hook2provided by RGD
    Official Full Name
    hook microtubule-tethering protein 2provided by RGD
    Primary source
    RGD:1310171
    See related
    EnsemblRapid:ENSRNOG00000003682 AllianceGenome:RGD:1310171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dynein light intermediate chain binding activity; identical protein binding activity; and microtubule binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to be located in cytosol and trans-Golgi network. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human HOOK2 (hook microtubule tethering protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 131.8), Testes (RPKM 119.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hook2 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40056732..40075027, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23151869..23170139, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26106713..26119353)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene guided entry of tail-anchored proteins factor 3, ATPase Neighboring gene bestrophin 2 Neighboring gene JunB proto-oncogene, AP-1 transcription factor subunit Neighboring gene peroxiredoxin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. Szebenyi G, et al. Traffic, 2007 Jan. PMID 17140400
    2. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Xu L, et al. Mol Biol Cell, 2008 Dec. PMID 18799622, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of FHF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of HOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein Hook homolog 2
    Names
    hook homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100562.1 → NP_001094032.1  protein Hook homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC099235, BQ203898, CB548211, CB696289, CB785578
      UniProtKB/TrEMBL
      E9PTX3
      Conserved Domains (2) summary
      pfam05622
      Location:8 → 706
      HOOK; HOOK protein
      pfam10267
      Location:260 → 344
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    2. NM_001415053.1 → NP_001401982.1  protein Hook homolog 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A6IY41
      Related
      ENSRNOP00000033999.5, ENSRNOT00000035987.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40056732..40075027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097685.2 → XP_038953613.1  protein Hook homolog 2 isoform X3

      UniProtKB/TrEMBL
      E9PTX3
      Conserved Domains (2) summary
      pfam05622
      Location:215 → 737
      HOOK; HOOK protein
      pfam19047
      Location:52 → 193
      HOOK_N; HOOK domain

    2. XM_039097684.2 → XP_038953612.1  protein Hook homolog 2 isoform X2

      UniProtKB/TrEMBL
      E9PTX3
      Related
      ENSRNOP00000108421.1, ENSRNOT00000128519.1
      Conserved Domains (2) summary
      pfam05622
      Location:215 → 738
      HOOK; HOOK protein
      pfam19047
      Location:52 → 193
      HOOK_N; HOOK domain

    3. XM_063277971.1 → XP_063134041.1  protein Hook homolog 2 isoform X7

    4. XM_039097683.2 → XP_038953611.1  protein Hook homolog 2 isoform X1

      UniProtKB/TrEMBL
      E9PTX3
      Conserved Domains (2) summary
      pfam05622
      Location:179 → 768
      HOOK; HOOK protein
      pfam19047
      Location:7 → 157
      HOOK_N; HOOK domain

    5. XM_006255258.5 → XP_006255320.1  protein Hook homolog 2 isoform X4

      UniProtKB/TrEMBL
      E9PTX3
      Conserved Domains (2) summary
      pfam05622
      Location:8 → 703
      HOOK; HOOK protein
      pfam10267
      Location:260 → 344
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    6. XM_063277969.1 → XP_063134039.1  protein Hook homolog 2 isoform X5

    7. XM_039097686.2 → XP_038953614.1  protein Hook homolog 2 isoform X8

      UniProtKB/TrEMBL
      Q4FZR1
      Conserved Domains (2) summary
      pfam05622
      Location:110 → 632
      HOOK; HOOK protein
      pfam19047
      Location:60 → 88
      HOOK_N; HOOK domain

    8. XM_063277972.1 → XP_063134042.1  protein Hook homolog 2 isoform X7

    9. XM_063277970.1 → XP_063134040.1  protein Hook homolog 2 isoform X6

      Related
      ENSRNOP00000103421.1, ENSRNOT00000133566.1

    RNA

    1. XR_010059990.1 RNA Sequence

    2. XR_010059991.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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